

Synthesis, characterization, biological activity and equilibrium studies of cadmium(II) with 2,6-diaminopyridine and various bio-relevant ligands
Azza Abdelwahab Shoukry (1,*)


(1) Department of Chemistry, Faculty of Science, Cairo University, 12613 Giza, Egypt
(2) Department of Chemistry, Faculty of Science for Girls, King Abdulaziz University, 50918 Jeddah, 21533 Kingdom of Saudi Arabia
(*) Corresponding Author
Received: 18 Apr 2013 | Revised: 23 May 2013 | Accepted: 29 May 2013 | Published: 30 Sep 2013 | Issue Date: September 2013
Abstract
The complexing properties of 2,6-diaminopyridine (DAP) with cadmium(II) were investigated via measuring pH (i.e., pH-metrically). Binary and ternary complexes of Cd(II) involving DAP and various biologically relevant ligands are investigated. The ligands used (L) were amino acids, dicarboxylic acids, amides and DNA unit constituents. The ternary complexes are formed by simultaneous reactions. The results showed the formation of Cd(DAP)(L) complexes with amino acids and dicarboxylic acids. Amides form both Cd(DAP)(L) complex and the corresponding deprotonated amide species Cd(DAP)(LH-1). The concentration distributions of the various complex species formed in solution were also evaluated as a function of pH. The effect of dioxane as a solvent on the protonation constant of DAP and the formation constants of Cd(II)-DAP complexes were discussed. The solid complexes [Cd(DAP)L)] where L = methionine and glycine, were isolated and characterized. The isolated solid complexes have also been screened for their antimicrobial activities against some selected bacteria and fungi. The activity data show that the complexes are found to have antibacterial and antifungal activity.

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DOI: 10.5155/eurjchem.4.3.260-267.800
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Microanalytical Center and the Bacteriology Laboratory of the Faculty of Science, Cairo University, Egypt
Citations
[1]. Azza Abdelwahab Shoukry
Complex formation equilibria of imipenem with some transition metal ions. Ternary complex formation reactions involving Cu(II) with imipenem and various bio-relevant ligands
European Journal of Chemistry 4(4), 379, 2013
DOI: 10.5155/eurjchem.4.4.379-387.868

[2]. Faten M. Ali Zainy, Aisha M. Turkustani, Azza A. Shoukry
Synthesis, Characterization, Physicochemical Studies and Antimicrobial Evaluation of Mixed Ligand Complexes Involving Co(II) with 2,2′-Dipyridylamine and Dicarboxylic Acids
Journal of Transition Metal Complexes 3, 1, 2020
DOI: 10.32371/jtmc/246098

[3]. Azza A. Shoukry, Saedah R. Al-Mhayawi
Solution Equilibria of Binary and Ternary Complexes Involving Zinc(II) with 2,6-Diaminopyridine and Various Biologically Relevant Ligands
Journal of Solution Chemistry 44(10), 2073, 2015
DOI: 10.1007/s10953-015-0395-0

[4]. Jihong Li, Yajun Zhou, Zongping Li, Zhiyuan Ma, Qingshu Ma, Lu Wang
Mechanism for improving the gel properties of transglutaminase-mediated porcine myofibrillar protein by ultrasonic pretreatment combined with carrageenan
Food Chemistry 426, 136635, 2023
DOI: 10.1016/j.foodchem.2023.136635

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