Mixed bivalent transition metal complexes of 1,10-phenanthroline and  2-aminomethylthiophenyl-4-bromosalicylaldehyde Schiff base: Spectroscopic, molecular modeling and biological activities

Mutlaq Shedeed Aljahdali; Ahmed Abdou El-Sherif; Rifaat Hasan Hilal; Abeer Taha Abdel-Karim

doi:10.5155/eurjchem.4.4.370-378.803

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Published: Dec 31, 2013

DOI: https://doi.org/10.5155/eurjchem.4.4.370-378.803

Keywords:

Schiff base, Bivalent metals, Biological activity, Antitumor activity, Electronic spectra, Mixed-ligand complexes

Section

Research Article

Issue

Vol. 4 No. 4 (2013): December 2013

Dates

Received 2013-04-21
Accepted 2013-06-26
Published 2013-12-31

Mutlaq Shedeed Aljahdali

Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia

Ahmed Abdou El-Sherif

Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

Rifaat Hasan Hilal

Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

Abeer Taha Abdel-Karim

Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

Abstract

Mixed ligand complexes of M(II) {M = Cu(II), Ni(II), Co(II) and Zn(II)} with 1,10-phenanthroline (1,10-Phen) and Schiff base namely 2-aminomethylthiophenyl-4-bromosalicylaldehyde (ATS) have been synthesized. These metal chelates have been characterized by elemental analyses, IR, ¹H NMR, solid reflectance, magnetic moment and molar conductance. Spectral data showed that the 1,10-phenanthroline act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms and Schiff base (ATS) acts as monobasic bidentate coordinating through through azomethine-N and phenolic-oxygen groups. The geometry of the studied M(II) complexes has been fully optimized. The metal chelates have been screened for their antimicrobial activities using the disc diffusion method against different selected types of bacteria and fungi. In vitro antitumor activity assayed against two human cell lines colon (HCT116) and larynx (HEP2) cancer cells. Solution equilibrium studies were also investigated.

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Aljahdali, M. S.; El-Sherif, A. A.; Hilal, R. H.; Abdel-Karim, A. T. Mixed Bivalent Transition Metal Complexes of 1,10-Phenanthroline and 2-Aminomethylthiophenyl-4-Bromosalicylaldehyde Schiff Base: Spectroscopic, Molecular Modeling and Biological Activities. Eur. J. Chem. 2013, 4, 370-378.

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