European Journal of Chemistry

Hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits in diabetic rat

Article Sidebar

PDF
Published: Mar 31, 2014
DOI: https://doi.org/10.5155/eurjchem.5.1.65-72.903
Keywords:
Alloxan, Antidiabetic, Hypoglycemic, Morus alba fruits, Morus nigra fruits, Lipid peroxidation
Section
Research Article
Issue
Vol. 5 No. 1 (2014): March 2014
Dates
Received 2013-08-11
Accepted 2013-09-15
Published 2014-03-31


Main Article Content

Hemdan Ibrahem Mahmoud
Agricultural Chemistry Department, Faculty of Agriculture, Minia University, 61517, Minia, Egypt
Said Mnaa Gad ElRab
Home Economics Department, Faculty of Specific Education, Menofia University, 23811, Ashmoon, Menofia, Egypt
Ayman Fathey Khalil
Home Economics Department, Faculty of Specific Education, Ain Shams University, 11566, Cairo, Egypt
Samah Mohamed Ismael
Home Economics Department, Faculty of Specific Education, Ain Shams University, 11566, Cairo, Egypt

Abstract

The aim of the present study was to investigate the hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits either used individually or in a combination on alloxan diabetic rats. These fruits are reported to be rich in antioxidants, flavonoids and phenolics that can potentially fight against diabetes mellitus. Male albino rats were divided into 5 groups: normal control, alloxan-diabetic control, diabetic rats treated with white mulberry fruit powder at 5% in the diet, diabetic rats treated with black mulberry fruit powder at 5% in the diet and diabetic rats treated with mixture of white and black mulberry fruits powder at 5% in the diet. After 4 weeks of treatment, blood glucose level, liver and kidney enzymes activity, lipid profile, lipid peroxidation and histopathological studies on liver, kidney and pancreas were evaluated. The mixture of white and black mulberry fruits showed the most significant (p < 0.05) improvement in feed efficiency ratio with increasing body weight gain, as well as decrease in blood glucose level and liver-kidney dysfunction when compared with diabetic control rats. Significant decrease in serum cholesterol, triglycerides and low density lipoprotein cholesterol (LDLc) as well as significant increase in high density lipoprotein cholesterol (HDLc) in diabetic rats was observed with all treatments. Moreover, mulberry fruits administration caused significant inhibition in lipid peroxidation and α-amylase activity. In addition, the beneficial effect of all treatments was further confirmed with histopathological examination of liver, kidney and pancreas. This study reveals hypoglycemic and hypolipidemic effects of white and black mulberry fruits either used individually or in combination as a dietary supplement in alloxan diabetic rats.


icon graph This Abstract was viewed 3607 times | icon graph Article PDF downloaded 1299 times

How to Cite
(1)
Mahmoud, H. I.; ElRab, S. M. G.; Khalil, A. F.; Ismael, S. M. Hypoglycemic Effect of White (Morus Alba L.) and Black (Morus Nigra L.) Mulberry Fruits in Diabetic Rat. Eur. J. Chem. 2014, 5, 65-72.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Danaei, G.; Finucane, M. M.; Lu, Y.; Singh, G. M.; Cowan, M. J.; Paciorek, C. J. Lin, J. K. Farzadfar, F.; Khang, Y. H.; Stevens, G. A.; Rao, M.; Ali, M. K.; Riley, L. M.; Robinson, C. A.; Ezzati, M. Lancet 2011, 378, 31-40.
http://dx.doi.org/10.1016/S0140-6736(11)60679-X

[2]. Herman, W. H.; Aubert, R. E.; Ali, M. A.; Sous, E. S.; Badran, A. East Mediterr. Health. J. 1997, 3, 144-148.

[3]. Bliss, M. The Discovery of Insulin. University of Chicago Press, Chicago, USA, 2000.

[4]. Gillies, C. L.; Abrams, K. R.; Lambert, P. C.; Cooper, N. J.; Sutton, A. J.; Hsu, R. T. BMJ 2007, 334(7588), 299-307.
http://dx.doi.org/10.1136/bmj.39063.689375.55

[5]. Rabbani, S. I.; Devi, K.; Khanam, S. Indian J. Exp. Biol. 2009, 47, 804-810.

[6]. Kar, A. B; Chaudhry, K.; Bandyopadhyay, N. C. J Ethnopharmacol. 2003, 24, 105-108.
http://dx.doi.org/10.1016/S0378-8741(02)00144-7

[7]. Jayakar, B.; Rajkapoor, S. B. J. Herb. Pharmacother. 2004, 4(1), 35-40.

[8]. Schiller, J. S.; Bernadel, L. Vital Health Stat. 2004, 3, 10-48.

[9]. Hasler, C. M.; Bloch, A. S.; Thomson, C. A.; Enrione, E.; Manning, C. J. Am. Diet. Assoc. 2004, 104(5), 814-826.
http://dx.doi.org/10.1016/j.jada.2004.03.015

[10]. Millen, B. E.; Quatromoni, P. A.; Pencia, M.; Kimokoti, R.; Mam, B.; Cobain, S. et al. J. Am. Diet. Assoc. 2005, 105, 1732-1734.
http://dx.doi.org/10.1016/j.jada.2005.08.007

[11]. Bazanno, L. A.; He, J.; Ogden, L. G.; Loria, C. M.; Vupputuri. S.; Myers, L.; Whelton, P. K. Am. J. Clin. Nutr. 2002, 76, 93-99.

[12]. Abd EI-Ghany, M. A. Egypt. J. Nutr. 2002, 17(3), 227-244.

[13]. Huang, T. H.; Kota, B. P.; Razmovski, V.; Roufogalis, B. D. Basic Clin. Pharmacol. Toxicol. 2005, 96, 3-14.
http://dx.doi.org/10.1111/j.1742-7843.2005.pto960102.x

[14]. Ning, D. W.; Lu, B.; Zhang, Y. L. China Fruit Veg. Proc. 2005, 5, 38-40.

[15]. Wattanathorn, J.; Muchimapura, S.; Thukhammee, W.; Tong-un, T.; Wannanon, P.; Nattaporn, P Pratchaya, K.; Thanes, C.; Wiroje, K.; Suttisan P.; Sathaporn, W. Am. J. Applied Sci. 2012, 9, 1503-1511.

[16]. Ma, Y. P. Xinjiang J. Trad. Chin. Med. 2002, 20, 83-84.

[17]. Gong, S. X.; Zhu, J. P. J. Zhejiang Univ. Trad. Chin. Med. 2008, 32, 350-352.

[18]. Shizhen, L. Compendium of Materia Medica. 1st ed. Foreign Language Press, ISBN-10, 7119032607, 2008.

[19]. Hamzaa, R. G.; El Shahat A. N.; Mekawey, H. M. S. Biochem. Anal. Biochem. 2012, 1(122), 1-8, doi:10. 4172/2161-1009. 1000122

[20]. Kojima, Y.; Kimura, T.; Nakagawa, K.; Asai, A.; Hasumi, K.; Oikawa, S. Miyazawa, T. J. Clin. Biochem. Nutr. 2010, 47, 155-161.
http://dx.doi.org/10.3164/jcbn.10-53

[21]. Kwon, H. J.; Chung, J. Y.; Kim, J. Y.; Kwon, O. J. Agric. Food Chem. 2011, 59, 3014-3019.
http://dx.doi.org/10.1021/jf103463f

[22]. Kostic, D. A.; Dimitrijevic, D. S.; Mitic, S. S.; Mitic, M. N., Stojanovic, G. S.; Zivanovic, A. V. Trop. J. Pharm. Res. 2013, 12(1), 105-110.

[23]. Naderi, G. A.; Asgary, S.; Sarraf-Zadegan, N.; Oroojy, H.; Afshin-Nia, F. Phytother. Res. 2004, 18, 365-369.
http://dx.doi.org/10.1002/ptr.1400

[24]. Hansawasdi, C.; Kawabata, J. Fitoterapia 2006, 77, 568-573.
http://dx.doi.org/10.1016/j.fitote.2006.09.003

[25]. Kaewkaen, P.; Tong-Un, T.; Wattanathorn, J.; Muchimapura, S.; Kaewrueng, W.; Wongcharoenwanakit, S. Am. J. Agric. Biol. Sci. 2012, 7 (3), 322-329.

[26]. Tsantili, E.; Shin, Y.; Nock, J. F.; Watkins, C. B. Postharvest Biol. Tec. 2010, 57, 27-34.
http://dx.doi.org/10.1016/j.postharvbio.2010.02.002

[27]. Chang, C. C.; Yang, M. H.; Wen, H. M.; Chern, J. C. J. Food Drug Anal. 2002, 10, 178-182.

[28]. Jakobek, L.; Seruga, M.; Medvidovic-Kosanovi, M.; Novak, I. Agric. Conspec. Sci. 2007, 72(4), 301-306.

[29]. Sheweita, A. A.; Newairy, H. A.; Mansour, M. I. Toxicology 2002, 174, 131-139.
http://dx.doi.org/10.1016/S0300-483X(02)00048-3

[30]. Zhang, J.; Huang, Y.; Hou, T.; Wang, Y. Swiss Med. Wkly. 2006, 136, 529-532.

[31]. Yang, X.; Yang, L.; Zheng, H. Food Chem. Toxicol. 2010, 48(8-9), 2374-2379.
http://dx.doi.org/10.1016/j.fct.2010.05.074

[32]. Trinder, P. Ann. Clin. Biochem. 1969, 6, 24-27.

[33]. Fossati, P.; Prencipe, L. Clin. Chem. 1982, 28, 2077-2080.

[34]. Richmond, W. Clin. Chem. 1973, 19, 1350-1356.

[35]. Lopes-Virella, M. F.; Stone, P.; Ellis, S.; Colwell, J. A. Clin. Chem. 1977, 23, 882-884.

[36]. Friedewald, W.; Levy, R.; Fredrickson, D. Clin. Chem. 1972, 18, 499-502.

[37]. Reitman, S.; Frankel, S. Am. J. Clin. Path. 1957, 28, 56-63.

[38]. Fawcett, J. K.; Scott, J. E. J. Clin. Path. 1960, 13, 156-159.
http://dx.doi.org/10.1136/jcp.13.2.156

[39]. Larsen, K. Clin. Chim. Acta 1972, 41, 209-217.
http://dx.doi.org/10.1016/0009-8981(72)90513-X

[40]. Ohkawa, H.; Ohishi, W.; Yagi, K. Anal. Biochem. 1979, 95(2), 351-358.
http://dx.doi.org/10.1016/0003-2697(79)90738-3

[41]. Rinderknecht, H.; Wilding, P.; Haverback, B. J. Experientia 1967, 23(10), 805-805.
http://dx.doi.org/10.1007/BF02146851

[42]. Banchroft, J.; Stevens, A.; Turner, D. Theory and practice of histological techniques. 4th ed. Churchil Livingstone, New York, London, San Francisco, Tokyo, 1996.

[43]. SPSS. Statistical Package for Social Science. Computer Software, Ver. 10. SPSS Company: London, UK, 1998.

[44]. Butkhup, L.; Samappito, W.; Samappito, S. Int. J. Food Sci. Tech. 2013, 48(5), 934-940.
http://dx.doi.org/10.1111/ijfs.12044

[45]. Ercisli, S.; Orhan, E. Food Chem. 2007, 103(4), 1380-1384.
http://dx.doi.org/10.1016/j.foodchem.2006.10.054

[46]. Zadernowski, R.; Naczk, M.; Nesterowicz, J. J. Agric. Food Chem. 2005, 53 (6), 2118-2124.
http://dx.doi.org/10.1021/jf040411p

[47]. Andallu, B.; Varadacharyulu, N. C. Clin. Chim. Acta 2003, 338, 3-10.
http://dx.doi.org/10.1016/S0009-8981(03)00322-X

[48]. Szkudelski, T. Physiol. Res. 2001, 50 (6), 537-546.

[49]. Chatterjea, M. N.; Shinde, R. Text book of medical biochemistry. 5th ed. New Delhi, Jaypee Brothers, Medical Publishers (P) Ltd., 2002.

[50]. Singab, A. N.; El-Beshbishy, H. A.; Yonekawa, M.; Nomura, T.; Fukai, T. J. Ethnopharmacol. 2005, 100, 333-338.
http://dx.doi.org/10.1016/j.jep.2005.03.013

[51]. Ma, D. Q.; Jiang, Z. J.; Xu, S. Q.; Yu, X.; Hu, X. M.; Pan, H. Y. Chinese Herb. Med. 2012, 4(4), 314-318.

[52]. Grover, J. K.; Yadav, S.; Vats, V. J. Ethnopharmacol. 2002, 81(1), 81-100.
http://dx.doi.org/10.1016/S0378-8741(02)00059-4

[53]. Chen, F. J.; Nakashima, N.; Kimura, M. Yakugaku Zasshi. 1995, 115, 476-482.

[54]. Zhang, X. M.; Liang, W. B.; Mao, Y. Q.; Li, H.; Yang, Y.; Tan, H. R. Biomed. Pharmacother. 2009, 63, 180-186.
http://dx.doi.org/10.1016/j.biopha.2007.07.006

[55]. Wohaieb, S. A.; Godin D. Y. Diabetes 1987, 3, 1014-1021.
http://dx.doi.org/10.2337/diab.36.9.1014

[56]. Chaudary, A. R.; Alam, M.; Ahmad, M. Fitoterapia 1993, 64, 510-515.

[57]. Chaurasia, S.; Saxena, R. C.; Chaurasia, I. D.; Shrivastava, R. Int. J. Chem. Sci. 2011, 9(2), 489-492.

[58]. Hui-Yin, C.; Gow-Chin, Y. Food Chem. 2007, 101, 686-694.
http://dx.doi.org/10.1016/j.foodchem.2006.02.047

[59]. Jarald, E. E. Joshi, S. B.; Jain, D. C. Indian J. Exp. Biol. 2008, 46, 660-667.

[60]. Shou-Chieh, W.; Shiow-Fen, L.; Chau-Jong, W.; Chao-Hsin, L.; Wen-Chin, L.; Huei-Jane, L. eCAM. 2009, 4, 1-9.

[61]. Shah, S. V.; Baliga, R.; Rajapurkar, M.; Fonseca, V. A. J. Am. Soc. Nephrol. 2007, 18, 16-28.
http://dx.doi.org/10.1681/ASN.2006050500

[62]. Jain, S.; Bhatia, G.; Barik, R.; Kumar, P.; Jain, A.; Dixit, V. K. J. Ethnopharmacol. 2010, 127, 325-328.
http://dx.doi.org/10.1016/j.jep.2009.10.038

[63]. Andallu, B.; Vinay Kumar, A. V.; Varadacharyulu, N. C. Int. J. Diabetes Dev. Ctries. 2009, 29(3), 123-128.
http://dx.doi.org/10.4103/0973-3930.54289

[64]. Lebovit, H. Diabetes Rev. 1998, 6, 132-145.

[65]. McDougall, G. J.; Stewart, D. Biofactors 2005, 23(4), 189-195.
http://dx.doi.org/10.1002/biof.5520230403

[66]. Farber, J. L.; Kyle, M. E.; Coleman, J. B. Lab. Invest. 1990, 62, 670-679.

[67]. Hamzaa, R. G.; Mekawey, H. M. S.; El Shahat, A. N. Arab J. Nucl. Sci. Appl. 2013, 46 (2), 347-355.

[68]. Baynes, J. W. Diabetes 1991, 40, 405-412.
http://dx.doi.org/10.2337/diab.40.4.405

[69]. Oh, H.; Ko, E. K.; Jun, J. Y.; Oh, M. H.; Park, S. U.; Kang, K. H.; Lee, H. S.; Kim, Y. C. Plant Med. 2002, 68, 932-934.
http://dx.doi.org/10.1055/s-2002-34930

[70]. Coskun, O.; Kanter, M.; Korkmaz, A.; Oter, S. Pharmacol. Res. 2005, 51, 117-123.
http://dx.doi.org/10.1016/j.phrs.2004.06.002

[71]. Mohammadi, J.; Naik, P. R. Turk. J. Biol. 2012, 36, 211-216.

Supporting Agencies

Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).