European Journal of Chemistry 2014, 5(2), 328-333. doi:10.5155/eurjchem.5.2.328-333.1025

Physicochemical studies and biological activity of mixed ligand complexes involving bivalent transition metals with a novel Schiff base and glycine as a representative amino acid


Abeer Taha Abedel Karim (1) , Ahmed Abdou El-Sherif (2,*)

(1) Department of Chemistry, Faculty of Science, Cairo University, Cairo, 12613 Egypt
(2) Department of Chemistry, Faculty of Arts and Science, Northern Borders University, Rafha, 156, Kingdom of Saudi Arabia
(*) Corresponding Author

Received: 29 Jan 2014, Accepted: 18 Feb 2014, Published: 30 Jun 2014

Abstract


The mixed-ligand complexes of Co(II), Ni(II), Mn(II) and Zn(II) with 2-aminomethyl thiophenyl-4-bromosalicylaldehyde Schiff base (ATS) and glycine as a representative example of amino acids have been achieved. These complexes namely [Ni(ATS)(Gly)] (1), [Co(ATS)(Gly)].H2O (2) [Mn(ATS)(Gly)].2H2O (3), and [Zn(ATS)(Gly)] (4) were characterized by elemental, molar conductance, infrared, magnetic moment, and electronic spectra. ATS behaves as mononegatively charged bidentate ligand with coordination through azomethine nitrogen and phenolate oxygen groups while glycine acts as monobasic bidentate ligand is coordinated via amino and ionized carboxylate group after deprotonation. The low molar conductance values suggest the non-electrolytic nature of these complexes. The magnetic and spectral data indicates a square planar geometry for Ni(II) complex, tetrahedral geometry for Zn(II) and octahedral geometry for both Mn(II) and Co(II) complexes. The isolated chelates have been screened for their antimicrobial activity.


Keywords


Glycine; Schiff base; Amino acid; Electronic spectra; Antibacterial activity; Mixed-ligand complexes

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DOI: 10.5155/eurjchem.5.2.328-333.1025

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[1]. Ahmed M. Rayan, Mahmoud M. Ahmed, Mohamed H. Barakat, Abeer T. Abdelkarim, Ahmed A. El-Sherif
Complex formation of cetirizine drug with bivalent transition metal(II) ions in the presence of alanine: synthesis, characterization, equilibrium studies, and biological activity studies
Journal of Coordination Chemistry  68(4), 678, 2015
DOI: 10.1080/00958972.2014.994513
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[2]. Abeer T. Abd El-Karim, Islam R. El-Sherif, Wafaa M. Hosny, Eyad K. Alkhadhairi, Mutlaq S. Aljahdali, Ahmed A. El-Sherif
Potentiometric and Speciation Studies on the Complex Formation Reactions of [Pd(2-methylaminomethyl)-pyridine)(H2O)2]2+ with Some Bio-active Ligands and Displacement Reaction of Coordinated Inosine
Journal of Solution Chemistry  46(5), 1024, 2017
DOI: 10.1007/s10953-017-0621-z
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References

[1]. Zimmermann, K. H. An Introduction to Protein Informatics, Kluwer Academic Publishers, London, 2003.
http://dx.doi.org/10.1007/978-1-4419-9210-9

[2]. Klement, R.; Stock, F.; Elias, H.; Paulus, H.; Pelikan, P.; Valko, M.; Mazur, M. Polyhedron 1999, 18, 3617-3628.
http://dx.doi.org/10.1016/S0277-5387(99)00291-0

[3]. Marchettic, F.; Pettinari, C.; Pettinari, R.; Cingolani, A.; Leanesi, D.; Lorenotti, A. Polyhedron 1999, 18, 3041-3050.
http://dx.doi.org/10.1016/S0277-5387(99)00230-2

[4]. Zhang, C.; Sun, J.; Kong, X.; Zhao, C. J. Coord. Chem. 2000, 50, 353-361.
http://dx.doi.org/10.1080/00958970008054940

[5]. Ramappa, P. G. J. Indian Chem. Soc. 1999, 76, 235-238.

[6]. Amirnasr, M.; Schenk, K. J.; Gorji, A.; Vafazadeh, R. Polyhedron 2001, 20, 695-702.
http://dx.doi.org/10.1016/S0378-3758(01)00095-7

[7]. Cmi, R.; Moore, S. J.; Marzilli, L. G. Inorg. Chem. 1998, 37, 6890-6897.
http://dx.doi.org/10.1021/ic980666i

[8]. Polson, S. M.; Cini, R.; Pifferi, C.; Marzilli, L. G. Inorg. Chem. 1997, 36, 314-322.
http://dx.doi.org/10.1021/ic961105z

[9]. Hirota, S.; Kosugi, E.; Marzilli, L. G.; Yamauchi, O. Inorg. Chim. Acta 1998, 275, 90-97.
http://dx.doi.org/10.1016/S0020-1693(97)06112-4

[10]. Martell, A. E.; Sawyer, D. T. Oxygen Complexes and Oxygen Activation by Transition Metals, Plenum Press, New York, 1988.
http://dx.doi.org/10.1007/978-1-4613-0955-0

[11]. Henson, N. J.; Hay, P. J.; Redondo, A. Inorg. Chem. 1999, 38, 1618-1626.
http://dx.doi.org/10.1021/ic9813056

[12]. Gurian, P. L.; Cheatham, L. K.; Ziller, J. W.; Barron, A. R. J. Chem. Soc. Dalton Trans. 1991, 1449-1456.
http://dx.doi.org/10.1039/dt9910001449

[13]. Labisbal, E.; Garcia-Vazquez, J. A.; Romero, J.; Picos, S.; Sousa, A. Polyhedron 1995, 14, 663-670.
http://dx.doi.org/10.1016/0277-5387(94)00292-M

[14]. Zolezzi, S.; Decinti, A.; Spodine, E. Polyhedron 1999, 18, 897-904.
http://dx.doi.org/10.1016/S0277-5387(98)00376-3

[15]. Pasini, A.; Demartin, F.; Piovesana, O.; Chiari, B.; Cinti, A.; Crispu, O. J. Chem. Soc. Dalton Trans. 2000, 3467-3472.
http://dx.doi.org/10.1039/b003825n

[16]. Sangeetha, N. R.; Pal, S. Polyhedron 2000, 19, 1593-1600.
http://dx.doi.org/10.1016/S0277-5387(00)00433-2

[17]. Jouad, E. l.; Riou, A.; Allain, M.; Khan, M. A.; Bouet, G. M. Polyhedron 2001, 20, 67-74.
http://dx.doi.org/10.1016/S0277-5387(00)00598-2

[18]. Nath, M.; Pokharia, S.; Yadav, R. Coord. Chem. Rev. 2001, 215, 99-107.
http://dx.doi.org/10.1016/S0010-8545(00)00404-5

[19]. Sharghi, H.; Nasser, M. A. Bull. Chem. Soc. (Jpn) 2003, 76, 137-142.
http://dx.doi.org/10.1246/bcsj.76.137

[20]. Gao, W. T.; Zheng, Z. Molecules 2001, 7, 511-516.
http://dx.doi.org/10.3390/70700511

[21]. Canpolat, E.; Kaya, M. J. Coord. Chem. 2004, 57, 127-134.

[22]. Fan, Y.; Bi, C.; Li, J. Synth. React. Inorg. Met. Org. Chem. 2003, 33, 137-145.
http://dx.doi.org/10.1081/SIM-120016878

[23]. Canpolat, E.; Kaya, M.; Yazici, A. Spectrosc. Lett. 2005, 38, 35-45.
http://dx.doi.org/10.1081/SL-200044740

[24]. Konstantinivi, S. S.; Radovanovi, B. C.; Caki, Z.; Vasic, V. J. Ser. Chem. Soc. 2003, 68, 641-648.
http://dx.doi.org/10.2298/JSC0309641K

[25]. Jeragh, B.; Al-Wahaib, D.; El-Sherif, A. A.; El-Dissouky, A. J. Chem. Eng. Data 2007, 52, 1609-1614.
http://dx.doi.org/10.1021/je600586e

[26]. El-Sherif, A. A. J. Solution Chem. 2006, 35, 1287-1301.
http://dx.doi.org/10.1007/s10953-006-9062-9

[27]. Mohamed, M. M. A.; El-Sherif, A. A. J. Solution Chem. 2010, 39, 639-653.
http://dx.doi.org/10.1007/s10953-010-9535-8

[28]. El-Sherif, A. A.; Shoukry, M. M. J. Coord. Chem. 2005, 58(16), 1401-1415.
http://dx.doi.org/10.1080/00958970500055435

[29]. El-Sherif, A. A.; Shoukry, M. M. Spectrochim. Acta A 2007, 66, 691-700.
http://dx.doi.org/10.1016/j.saa.2006.04.013

[30]. El-Sherif, A. A.; Shoukry, M. M. Inorg. Chim. Acta 2007, 360, 473-487.
http://dx.doi.org/10.1016/j.ica.2006.07.108

[31]. El-Sherif, A. A.; Eldebss, T. M. Spectrochim. Acta A 2011, 79, 1803-1814.
http://dx.doi.org/10.1016/j.saa.2011.05.062

[32]. Pfaller, M. A.; Burmeister, L.; Bartlett, M. A.; Rinaldi, M. G. J. Clin. Microbiol. 1988, 26, 1437-1441.

[33]. Liebowitz, L. D.; Ashbee, H. R.; Evans, E. G. V.; Chong, Y.; Mallatova, N.; Zaidi, M.; Gibbs, D. Microbiol. Infet. Dis. 2001, 24, 27-33.
http://dx.doi.org/10.1016/S0732-8893(01)00243-7

[34]. Bauer, A. W.; Kirby, W. M.; Sherris, C.; Turck, M. J. Am. Clin. Path. 1996, 45, 493-499.

[35]. El-Sherif, A. A.; Shehata, M. R.; Shoukry, M. M.; Barakat, M. H. J. Spectrochim. Acta A 2012, 96, 889-897.
http://dx.doi.org/10.1016/j.saa.2012.07.047

[36]. Kulkarni, A.; Patil, S. A.; Badami, P. S. Eur. J. Med. Chem. 2009, 44, 2904-2912.
http://dx.doi.org/10.1016/j.ejmech.2008.12.012

[37]. Sarkar, S.; Dey, K. Spectrochim. Acta A 2005, 62, 383-393.
http://dx.doi.org/10.1016/j.saa.2005.01.005

[38]. West, D. X.; Nassar, A. A. Trans. Met. Chem. 1998, 23, 321-326.
http://dx.doi.org/10.1023/A:1006957325074

[39]. Bagihalli, G. B.; Avaji, P. G.; Patil, S. A.; Badami, P. S. Eur. J. Med. Chem. 2008, 43, 2639-2649.
http://dx.doi.org/10.1016/j.ejmech.2008.02.013

[40]. Gronowitz, S.; Katritsky, A. R.; Reavill, R. E. J. Am. Chem. Soc. 1964, 86, 3881-3882.
http://dx.doi.org/10.1021/ja01072a062

[41]. El-Sherif, A. A.; Aljahdali, M. S.; Hilal, R. H. Eur. J. Chem. 2013, 4(4), 370-378.
http://dx.doi.org/10.5155/eurjchem.4.4.370-378.803

[42]. Nakamoto, K.; Infrared Raman Spectra of Inorganic and Coordination Compounds, Third ed., John Wiley and Sons, New York, 1992.

[43]. Decon, G. B.; Philips, R. J. Coord. Rev. 1980, 33, 227-250.
http://dx.doi.org/10.1016/S0010-8545(00)80455-5

[44]. Aljahdali, M. S. Spectrochim. Acta A 2013, 112, 364-376
http://dx.doi.org/10.1016/j.saa.2013.03.057

[45]. El-Sherif, A. A.; Shoukry, M. M.; Abobakr, L. O. J. Spectrochim. Acta A 2013, 112, 290-300
http://dx.doi.org/10.1016/j.saa.2013.04.023

[46]. Stefov, V.; Petrusevski, V. M.; Soptrajanov, B. J. Mol. Struct. 1993, 293, 97-100.
http://dx.doi.org/10.1016/0022-2860(93)80024-P

[47]. Aljahdali, M.; El-Sherif, A. A. Inorg. Chim. Acta 2013, 407, 58-68.
http://dx.doi.org/10.1016/j.ica.2013.06.040

[48]. Aljahdali, M. S. Eur. J. Chem. 2013, 4(4), 434-443.
http://dx.doi.org/10.5155/eurjchem.4.4.434-443.838

[49]. El-Sherif, A. A.; Shoukry, M. M.; Abd-Elgawad, M. M. A. J. Spectrochim. Acta A 2012, 98, 307-321.
http://dx.doi.org/10.1016/j.saa.2012.08.034

[50]. Dingle, R. Inorg. Chem. 1971, 10, 1141-1144.
http://dx.doi.org/10.1021/ic50100a007

[51]. Shrivastav, A.; Kishore, N.; Singh, S. M. Biometals 2003, 16(2), 311-320.
http://dx.doi.org/10.1023/A:1020611428001

[52]. Khalil, S. M. E.; El-Shafiy, H. F. O. Synth. React. Inorg. Met. Org. Chem. 2000, 30, 1817-1826.
http://dx.doi.org/10.1080/00945710009351871

[53]. Schlapp, R.; Penney, W. G. Phys. Rev. 1932, 42, 666-686.
http://dx.doi.org/10.1103/PhysRev.42.666

[54]. Figgis, B. N.; Nyhlom, R. S. J. Chem. Soc. 1958, 4190-4200.
http://dx.doi.org/10.1039/jr9580004190

[55]. Salib, K. A. R.; Saleh, A. A.; Abu El-Wafa, S.; El-Shafiy, H. F. O. J. Coord. Chem. 2003, 56(4), 283-291.
http://dx.doi.org/10.1080/0095897031000069021

[56]. El-Sherif, A. A. J. Solution Chem. 2010, 39, 1562-1581.
http://dx.doi.org/10.1007/s10953-010-9593-y

[57]. Bailar, J. C.; Emeleus, H. J.; Nyhlom, R.; Trotmon-Dickenson, A. F., Comprehensive Inorg. Chem., Pergamon Press, New York 1975, 3, pp. 1048, 1049, 1089, 1093, 1153.

[58]. Mishra, R. C.; Mohapatra, B. K.; Panda, D. J. Indian Chem. Soc. 1983, 60, 782-790.

[59]. Sanmartin, J.; Bermejo, M. R.; Deibe, A. M. G.; Maneiro, M.; Lage, C.; Filho, A. J. C. Polyhedron 2000, 19, 185-192.
http://dx.doi.org/10.1016/S0277-5387(99)00341-1

[60]. Krzyminiewska, V. P.; Litkowska, H.; Paryzek, W. R. Monatsh. Chem. 1999, 130, 243-249.

[61]. Melnik, M.; Gyoryova, K.; Skorsepa, J.; Holloway, C. E. J. Coord. Chem. 1995, 35, 179-185.
http://dx.doi.org/10.1080/00958979508024038

[62]. British Pharmacopia, Her Majesty's Stationery Office, London, UK, 1998, p. 1040.

[63]. Cakir, S.; Bicer, E.; Odabasoglu, M.; Albayrak, C. J. Braz. Chem. Soc. 2005, 4, 711-717.
http://dx.doi.org/10.1590/S0103-50532005000500005

[64]. Koch, A. L. Clin. Microbiol. Rev. 2003, 16, 673-678.
http://dx.doi.org/10.1128/CMR.16.4.673-687.2003

[65]. Chohan, Z. H.; Scozzafava, A.; Supran, C. T. J. Enzym Inhib. Med. Ch. 2003, 17, 261-269.
http://dx.doi.org/10.1080/1475636021000006261

[66]. Chohan, Z. H.; Khan, K. M.; Supuran, C. T. Appl. Organomet. Chem. 2004, 18, 305-310.
http://dx.doi.org/10.1002/aoc.620


How to cite


Karim, A.; El-Sherif, A. Eur. J. Chem. 2014, 5(2), 328-333. doi:10.5155/eurjchem.5.2.328-333.1025
Karim, A.; El-Sherif, A. Physicochemical studies and biological activity of mixed ligand complexes involving bivalent transition metals with a novel Schiff base and glycine as a representative amino acid. Eur. J. Chem. 2014, 5(2), 328-333. doi:10.5155/eurjchem.5.2.328-333.1025
Karim, A., & El-Sherif, A. (2014). Physicochemical studies and biological activity of mixed ligand complexes involving bivalent transition metals with a novel Schiff base and glycine as a representative amino acid. European Journal of Chemistry, 5(2), 328-333. doi:10.5155/eurjchem.5.2.328-333.1025
Karim, Abeer, & Ahmed Abdou El-Sherif. "Physicochemical studies and biological activity of mixed ligand complexes involving bivalent transition metals with a novel Schiff base and glycine as a representative amino acid." European Journal of Chemistry [Online], 5.2 (2014): 328-333. Web. 19 Nov. 2019
Karim, Abeer, AND El-Sherif, Ahmed. "Physicochemical studies and biological activity of mixed ligand complexes involving bivalent transition metals with a novel Schiff base and glycine as a representative amino acid" European Journal of Chemistry [Online], Volume 5 Number 2 (30 June 2014)

DOI Link: https://doi.org/10.5155/eurjchem.5.2.328-333.1025

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