European Journal of Chemistry 2015, 6(1), 84-87. doi:10.5155/eurjchem.6.1.84-87.1149

Synthesis and antioxidant evaluation of some new pyridines


Moustafa Ahmed Gouda (1,*) , Mohamed Hamdy Helal (2)

(1) Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
(2) Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, 1321, Kingdom of Saudi Arabia
(*) Corresponding Author

Received: 09 Sep 2014, Accepted: 09 Oct 2014, Published: 31 Mar 2015

Abstract


One-pot condensation of malononitrile (1), 4-methylpentan-2-one (2), aryl carboxaldehyde (3a-f) and ammonium acetate in ethanol afforded 2-amino-5-isopropyl-4-(4-aryl)-6-methylnicotinonitriles (4a-f). The antioxidant activity of the new synthesized compounds was evaluated and the result showed all compound exhibited weak anti-oxidant activities.


Keywords


Pyridine; Malononitrile; Nicotinonitrile; Antioxidant activity; Aryl carboxaldehyde; 4-Methylpentan-2-one

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DOI: 10.5155/eurjchem.6.1.84-87.1149

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Citations

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[1]. M. A. Salem, M. H. Helel, M. A. Gouda, Y. A. Ammar, M. S. A. El-Gaby
Overview on the synthetic routes to nicotine nitriles
Synthetic Communications  48(4), 345, 2018
DOI: 10.1080/00397911.2017.1394468
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[2]. Moustafa A. Gouda, Ehab Attia, Mohamed H. Helal, Mohammed A. Salem
Recent Progress on Nicotinonitrile Scaffold-based Anticancer, Antitumor, and Antimicrobial Agents: A Literature Review
Journal of Heterocyclic Chemistry  55(10), 2224, 2018
DOI: 10.1002/jhet.3298
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[3]. Moustafa A. Gouda, Moged A. Berghot, Ghada E. Abd El-Ghani, Abd El-Galil M. Khalil
Synthesis of Some Novel 4-(Furan-2-yl)-5,6-dimethylpyridines
Journal of Heterocyclic Chemistry  55(8), 1935, 2018
DOI: 10.1002/jhet.3231
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[4]. Moustafa A. Gouda, Ghada E. Abd El‐Ggani, Moged A. Berghot, Abd El‐Galil M. Khalil
Synthesis and Antioxidant Activity of Some Novel Nicotinonitrile Derivatives Bearing a Furan Moiety
Journal of Heterocyclic Chemistry  56(7), 2036, 2019
DOI: 10.1002/jhet.3584
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[5]. Moustafa A. Gouda, Belal H. M. Hussein, Mohamed H. Helal, Mohammed A. Salem
A Review: Synthesis and Medicinal Importance of Nicotinonitriles and Their Analogous
Journal of Heterocyclic Chemistry  55(7), 1524, 2018
DOI: 10.1002/jhet.3188
/


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How to cite


Gouda, M.; Helal, M. Eur. J. Chem. 2015, 6(1), 84-87. doi:10.5155/eurjchem.6.1.84-87.1149
Gouda, M.; Helal, M. Synthesis and antioxidant evaluation of some new pyridines. Eur. J. Chem. 2015, 6(1), 84-87. doi:10.5155/eurjchem.6.1.84-87.1149
Gouda, M., & Helal, M. (2015). Synthesis and antioxidant evaluation of some new pyridines. European Journal of Chemistry, 6(1), 84-87. doi:10.5155/eurjchem.6.1.84-87.1149
Gouda, Moustafa, & Mohamed Hamdy Helal. "Synthesis and antioxidant evaluation of some new pyridines." European Journal of Chemistry [Online], 6.1 (2015): 84-87. Web. 14 Nov. 2019
Gouda, Moustafa, AND Helal, Mohamed. "Synthesis and antioxidant evaluation of some new pyridines" European Journal of Chemistry [Online], Volume 6 Number 1 (31 March 2015)

DOI Link: https://doi.org/10.5155/eurjchem.6.1.84-87.1149

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