European Journal of Chemistry 2010, 1(3), 200-205. doi:10.5155/eurjchem.1.3.200-205.120

Synthesis, characterization and antibacterial activity of nickel (II) and copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide


Sohail Saeed (1,*) , Naghmana Rashid (2) , Muhammad Ali (3) , Rizwan Hussain (4)

(1) Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, 44000, Pakistan
(2) Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, 44000, Pakistan
(3) Department of Pharmacy, University of The Punjab, Lahore, 54590, Pakistan
(4) National Engineering & Scientific Commission, P.O. Box 2801, Islamabad, Pakistan
(*) Corresponding Author

Received: 21 May 2010, Accepted: 22 Jul 2010, Published: 29 Sep 2010

Abstract


Nickel and copper metal complexes of N-(R-carbamothioyl)-4-nitrobenzamide (R = diphenyl and ethylbutyl) were synthesized and characterized by IR, 1H NMR, mass spectrometry and elemental analysis. The spectroscopic data are consistent with the ligand and the metal complexes containing two O and S chelated ligands. N-(diphenylcarbamothioyl)-4-nitrobenzamide, HL1, was characterized by a single crystal X-ray diffraction study. It crystallizes in the triclinic space group P  with unit cell dimensions of a = 6.8044(4) Å, b = 10.0113(6) Å, c = 13.2365(8) Å, α = 6.8044(4) °, β = 78.171(4) °, γ = 13.2365(8)°, V = 882.43(9) Å3. The ligands coordinate as bidentates yielding essentially neutral complexes of the type [ML2]. The ligands and complexes were screened for their in vitro antibacterial activities and comparatively the complexes showed greater antibacterial efficacy than the thiourea derivative ligands.

1_3_200_205_800


Keywords


Thiourea derivatives; Transition metal complexes; X-ray structure determination; Phase-transfer catalyst; Antibacterial activity

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DOI: 10.5155/eurjchem.1.3.200-205.120

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How to cite


Saeed, S.; Rashid, N.; Ali, M.; Hussain, R. Eur. J. Chem. 2010, 1(3), 200-205. doi:10.5155/eurjchem.1.3.200-205.120
Saeed, S.; Rashid, N.; Ali, M.; Hussain, R. Synthesis, characterization and antibacterial activity of nickel (II) and copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide. Eur. J. Chem. 2010, 1(3), 200-205. doi:10.5155/eurjchem.1.3.200-205.120
Saeed, S., Rashid, N., Ali, M., & Hussain, R. (2010). Synthesis, characterization and antibacterial activity of nickel (II) and copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide. European Journal of Chemistry, 1(3), 200-205. doi:10.5155/eurjchem.1.3.200-205.120
Saeed, Sohail, Naghmana Rashid, Muhammad Ali, & Rizwan Hussain. "Synthesis, characterization and antibacterial activity of nickel (II) and copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide." European Journal of Chemistry [Online], 1.3 (2010): 200-205. Web. 22 Nov. 2019
Saeed, Sohail, Rashid, Naghmana, Ali, Muhammad, AND Hussain, Rizwan. "Synthesis, characterization and antibacterial activity of nickel (II) and copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide" European Journal of Chemistry [Online], Volume 1 Number 3 (29 September 2010)

DOI Link: https://doi.org/10.5155/eurjchem.1.3.200-205.120

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