European Journal of Chemistry

Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives

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Published: Sep 29, 2010
DOI: https://doi.org/10.5155/eurjchem.1.3.221-227.124
Keywords:
Thiourea derivatives, Thiophene, Single crystal structure determination, Mass fragmentation, Antifungal activity
Section
Research Article
Issue
Vol. 1 No. 3 (2010): September 2010
Dates
Received 2010-05-23
Accepted 2010-07-19
Published 2010-09-29


Main Article Content

Sohail Saeed
Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, 44000, Pakistan
Naghmana Rashid
Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, 44000, Pakistan
Muhammad Ali
Department of Pharmacy, University of the Punjab, Lahore, 54590, Pakistan
Rizwan Hussain
National Engineering & Scientific Commission, P.O. Box 2801, Islamabad, Pakistan
Peter G. Jones
Institut für Anorganische und Analytische Chemie, Technische Universität Braunschweig, Braunschweig, D-38023, Germany

Abstract

This article presents our research concerning the synthesis of new thiophene-thiourea derivatives (1-12) and their pharmacological properties. These novel thiophene-thiourea derivatives were synthesized and characterized by IR, 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. The crystal structure of N,N-diphenyl-N'-(thiophene-2-carbonyl)-thiourea was determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21 with unit cell dimensions of a=11.7469(5) Å, b=6.0849(2) Å, c=12.5792(6) Å, β= 117.736(7) ° and V = 795.8(6) Å3. The mass fragmentation pattern has also been discussed. The synthesized compounds were screened for their in vitro antifungal activities against the standard strains: C. Albicans, C. Glabrata, and C. Tropicalis. The compounds N-thiophene-N',N'-bis(dimethyl-phosphinoylmethyl)thiourea, N-[(4-nitro-1H-imidazol-2-yl)carbamothioyl]thiophene-2-carboxamide and N,N-diethyl-N'-(thiophene-2-carbonyl)-thiourea showed significant antifungal activities against microbial species.

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Saeed, S.; Rashid, N.; Ali, M.; Hussain, R.; Jones, P. G. Synthesis, Spectroscopic Characterization, Crystal Structure and Pharmacological Properties of Some Novel Thiophene-Thiourea Core Derivatives. Eur. J. Chem. 2010, 1, 221-227.

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