European Journal of Chemistry 2016, 7(1), 30-36. doi:10.5155/eurjchem.7.1.30-36.1350

Spectrophotometric methods for analysis of different dosage forms containing pyridoxine hydrochloride


Neven Magdy Habib (1,*) , Nada Sayed Abdelwhab (2) , Maha Mohamed Abdelrahman (3) , Nourudin Wageih Ali (4)

(1) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt
(2) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt
(3) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt
(4) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt
(*) Corresponding Author

Received: 24 Oct 2015, Accepted: 22 Nov 2015, Published: 31 Mar 2016

Abstract


Two accurate, precise, sensitive and selective spectrophotometric methods have been developed and validated for determination of pyridoxine hydrochloride (PYH), cyclizine hydrochloride (CYH) and meclizine hydrochloride (MEH) either in their binary mixtures or in synthetic ternary mixtures. In modified area under the curve method (Method I), PYH has been determined by measuring amplitude value of the plateau at 283 nm (obtained after dividing the ternary mixture by standard spectrum of 20 µg/mL of PYH at which no interference from CYH and MEH) while area under the curve spectrophotometric method (AUC) has been used for calculating CYH and MEH concentrations in the ternary mixture by measuring the area under the curve in the range of 215-228 and 230-243 nm in the obtained division spectrum and after subtraction of the constant value at 283 nm. Method II is mean centering of ratio spectra spectrophotometric method (MCR) at which the mean centered ratio spectra in two successive steps have been used for measuring the amplitudes of the mean centered second ratio spectra amplitudes at 228.8, 262.0 and 270.8 nm for PYH, CYH and MEH, respectively. The proposed methods were successfully applied for determination of the cited drugs in their pharmaceutical formulations. Also they were statistically compared with the reported methods using student's-t and F-tests and there was no significant difference between them regarding both accuracy and precision.


Keywords


Cyclizine HCl; Dosage forms; Meclizine HCl; Pyridoxine HCl; Spectrophotometric methods; Determination of pyridoxine hydrochloride

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DOI: 10.5155/eurjchem.7.1.30-36.1350

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Citations

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[1]. Ahmed A. Khorshed, Mohamed Khairy, Craig E. Banks
Voltammetric determination of meclizine antihistamine drug utilizing graphite screen-printed electrodes in physiological medium
Journal of Electroanalytical Chemistry  824, 39, 2018
DOI: 10.1016/j.jelechem.2018.07.029
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[2]. Maha M. Abdelrahman, Selvia M. Adly, Nourudin W. Ali, Nada S. Abdelwahab
Development and Validation of Different Spectrophotometric and High-Performance Thin-Layer Chromatographic Methods for the Determination of Fosinopril Sodium, Hydrochlorothiazide, and Chlorothiazide as Hydrochlorothiazide Impurity
JPC - Journal of Planar Chromatography - Modern TLC  32(5), 411, 2019
DOI: 10.1556/1006.2019.32.5.9
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How to cite


Habib, N.; Abdelwhab, N.; Abdelrahman, M.; Ali, N. Eur. J. Chem. 2016, 7(1), 30-36. doi:10.5155/eurjchem.7.1.30-36.1350
Habib, N.; Abdelwhab, N.; Abdelrahman, M.; Ali, N. Spectrophotometric methods for analysis of different dosage forms containing pyridoxine hydrochloride. Eur. J. Chem. 2016, 7(1), 30-36. doi:10.5155/eurjchem.7.1.30-36.1350
Habib, N., Abdelwhab, N., Abdelrahman, M., & Ali, N. (2016). Spectrophotometric methods for analysis of different dosage forms containing pyridoxine hydrochloride. European Journal of Chemistry, 7(1), 30-36. doi:10.5155/eurjchem.7.1.30-36.1350
Habib, Neven, Nada Sayed Abdelwhab, Maha Mohamed Abdelrahman, & Nourudin Wageih Ali. "Spectrophotometric methods for analysis of different dosage forms containing pyridoxine hydrochloride." European Journal of Chemistry [Online], 7.1 (2016): 30-36. Web. 7 Dec. 2019
Habib, Neven, Abdelwhab, Nada, Abdelrahman, Maha, AND Ali, Nourudin. "Spectrophotometric methods for analysis of different dosage forms containing pyridoxine hydrochloride" European Journal of Chemistry [Online], Volume 7 Number 1 (31 March 2016)

DOI Link: https://doi.org/10.5155/eurjchem.7.1.30-36.1350

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