European Journal of Chemistry

Synthesis of some novel pyridine and naphthyridine derivatives

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Published: Dec 22, 2010
DOI: https://doi.org/10.5155/eurjchem.1.4.368-372.104
Keywords:
Fur-2-ylethylidenemalononitrile, Thien-2-ylethylidenemalononitrile, Dihydro-pyridines, Pyrazolo-naphthyridines, Pyrimido-naphthyridines
Section
Research Article
Issue
Vol. 1 No. 4 (2010): December 2010
Dates
Received 2010-05-09
Accepted 2010-07-15
Published 2010-12-22


Main Article Content

Fathy Mohamed Abdelrazek
Chemistry Department, Faculty of Science, Cairo University, Giza, EG-12613, Egypt
Nazmi Abdel-Latif Kassab
Chemistry Department, Faculty of Science, Cairo University, Giza, EG-12613, Egypt
Nadia Hanafy Metwally
Chemistry Department, Faculty of Science, Cairo University, Giza, EG-12613, Egypt
Nehal Ahmed Sobhy
Chemistry Department, Faculty of Science, Cairo University, Giza, EG-12613, Egypt

Abstract

2-[1-(Furan- or thiophen-2-yl)ethylidene)malononitriles (1a,b) undergo dimerization reactions in ethanol catalyzed by sodium ethoxide to afford 2-[4,6-di(furan- or thiophen-2-yl)-3-cyano-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]malononitrile derivatives (2a,b), respectively. Compounds 2a and 2b couple with arene diazonium salts (3a-c) to afford the hydrazo derivatives (4a-f). They react also with hydrazines (5a,b) to afford the pyrazolo[3,4-H][1,6]naphthyridine derivatives (6a-d) and with urea derivatives (7a-c) to afford the pyrimido[4,5-H][1,6]naphthyridine derivatives (8a-f), respectively.

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Abdelrazek, F. M.; Kassab, N. A.-L.; Metwally, N. H.; Sobhy, N. A. Synthesis of Some Novel Pyridine and Naphthyridine Derivatives. Eur. J. Chem. 2010, 1, 368-372.

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