European Journal of Chemistry

Chemical constituents and cytotoxic activities of the extracts of Melilotus indicus

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Published: Sep 30, 2014
DOI: https://doi.org/10.5155/eurjchem.5.3.503-506.1070
Keywords:
Fabaceae, Phenolics, Flavonoids, Melilotus indicus, Cytotoxic activity, Phytochemical studies
Section
Research Article
Issue
Vol. 5 No. 3 (2014): September 2014
Dates
Received 2014-04-07
Accepted 2014-05-13
Published 2014-09-30


Main Article Content

Sayed Abdel Kader Ahmed
Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt
Mahmoud Al-Refai
Department of Chemistry , Faculty of Science, Al Al-Bayt University, Mafraq, 25113, Jordan

Abstract

The phytochemical investigation of the ethanolic extract of the aerial parts of Melilotus indicus resulted in the isolation of eight known flavonoids, namely; catechin (1), epicatechin (2), taxifolin (3), quercetin (4), quercetin 3-O-β-D-glucopyranoside (5), and quercetin 3-O-α-L-rhamnopyranoside (6), isorhamnetin 3-O-β-D-glucopyranoside (7) and isorhamnetin 3-O-β-D-rutinoside (8). These compounds have never been isolated from this species. The cytotoxic activities of the extracts of Melilotus indicus was evaluated by MTT assay against six cancer cell lines using doxorubicin as standard drug. The chloroform extract was the most potent cytotoxic agent against HepG-2cells with an IC50: 9.21 µg/mL.


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Ahmed, S. A. K.; Al-Refai, M. Chemical Constituents and Cytotoxic Activities of the Extracts of Melilotus Indicus. Eur. J. Chem. 2014, 5, 503-506.

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