European Journal of Chemistry

Synthesis and antioxidant evaluation of some new pyridines

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Published: Mar 31, 2015
DOI: https://doi.org/10.5155/eurjchem.6.1.84-87.1149
Keywords:
Pyridine, Malononitrile, Nicotinonitrile, Antioxidant activity, Aryl carboxaldehyde, 4-Methylpentan-2-one
Section
Research Article
Issue
Vol. 6 No. 1 (2015): March 2015
Dates
Received 2014-09-09
Accepted 2014-10-09
Published 2015-03-31


Main Article Content

Moustafa Ahmed Gouda
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Mohamed Hamdy Helal
Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, 1321, Kingdom of Saudi Arabia

Abstract

One-pot condensation of malononitrile (1), 4-methylpentan-2-one (2), aryl carboxaldehyde (3a-f) and ammonium acetate in ethanol afforded 2-amino-5-isopropyl-4-(4-aryl)-6-methylnicotinonitriles (4a-f). The antioxidant activity of the new synthesized compounds was evaluated and the result showed all compound exhibited weak anti-oxidant activities.


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Gouda, M. A.; Helal, M. H. Synthesis and Antioxidant Evaluation of Some New Pyridines. Eur. J. Chem. 2015, 6, 84-87.

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