Synthesis, characterization and antibacterial activity of nickel (II) and        copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide

Sohail Saeed; Naghmana Rashid; Muhammad Ali; Rizwan Hussain

doi:10.5155/eurjchem.1.3.200-205.120

PDF

Published: Sep 29, 2010

DOI: https://doi.org/10.5155/eurjchem.1.3.200-205.120

Keywords:

Thiourea derivatives, Transition metal complexes, X-ray structure determination, Phase-transfer catalyst, Antibacterial activity

Section

Research Article

Issue

Vol. 1 No. 3 (2010): September 2010

Dates

Received 2010-05-21
Accepted 2010-07-22
Published 2010-09-29

Sohail Saeed

Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, 44000, Pakistan

Naghmana Rashid

Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, 44000, Pakistan

Muhammad Ali

Department of Pharmacy, University of The Punjab, Lahore, 54590, Pakistan

Rizwan Hussain

National Engineering & Scientific Commission, P.O. Box 2801, Islamabad, Pakistan

Abstract

Nickel and copper metal complexes of N-(R-carbamothioyl)-4-nitrobenzamide (R = diphenyl and ethylbutyl) were synthesized and characterized by IR, ¹H NMR, mass spectrometry and elemental analysis. The spectroscopic data are consistent with the ligand and the metal complexes containing two O and S chelated ligands. N-(diphenylcarbamothioyl)-4-nitrobenzamide, HL¹, was characterized by a single crystal X-ray diffraction study. It crystallizes in the triclinic space group P with unit cell dimensions of a = 6.8044(4) Å, b = 10.0113(6) Å, c = 13.2365(8) Å, α = 6.8044(4) °, β = 78.171(4) °, γ = 13.2365(8)°, V = 882.43(9) Å³. The ligands coordinate as bidentates yielding essentially neutral complexes of the type [ML₂]. The ligands and complexes were screened for their in vitro antibacterial activities and comparatively the complexes showed greater antibacterial efficacy than the thiourea derivative ligands.

1_3_200_205_800

This Abstract was viewed 3917 times |

Article PDF downloaded 1257 times

How to Cite

(1)

Saeed, S.; Rashid, N.; Ali, M.; Hussain, R. Synthesis, Characterization and Antibacterial Activity of Nickel (II) and Copper (II) Complexes of N-(alkyl(aryl)carbamothioyl)-4-Nitrobenzamide. Eur. J. Chem. 2010, 1, 200-205.

Links for Article

Crossref - Scopus - Google - European PMC

References

[1]. Arslan, H.; Flörke, U.; Külcü, N. Trans. Metal Chem. 2003, 28, 816-819.
doi:10.1023/A:1026064232260

[2]. Moloto, M. J.; Malik, M. A.; O’Brien. P.; Motevalli, M.; Kolawole, G. A. Polyhedron 2003, 22, 595-603.
doi:10.1016/S0277-5387(02)01420-1

[3]. Henderson, W.; Nicholson, B. K.; Dinger, M. B.; Bennett, R. L. Inorg. Chim. Acta, 2002, 338, 210-218.
doi:10.1016/S0020-1693(02)01017-4

[4]. Mansuroglu, D. S.; Arslan, H.; Flörke, U.; Külcü, N. J. Coord. Chem. 2008, 61, 3134-3146.
doi:10.1080/00958970802010567

[5]. Arslan, H.; Flörke, U.; Külcü, N.; Emen, M. F. J. Coord. Chem. 2006, 59, 223-228.
doi:10.1080/00958970500270992

[6]. Lipowska, M.; Hayes, B. L.; Hansen, L.; Taylor, A.; Marzilli, L. G. Inorg. Chem. 1996, 35, 4227-4231.
doi:10.1021/ic9514657
PMid:11666632

[7]. Dominguez, M.; Antico, E.; Beyer, L.; Aguirre, A.; Garcia-Granda, S.; Salvado, V. Polyhedron 2002, 21, 1429-1437.
doi:10.1016/S0277-5387(02)00948-8

[8]. Zhang, Y. M.; Pang, H. X; Cao, C.; Wei, T. B. J. Coord. Chem. 2008, 61, 1663-1670.
doi:10.1080/00958970701615888

[9]. Dechamps-Olivier, I.; Guillon, E.; Mohamadou, A.; Barbier, J. P. Polyhedron 1996, 15, 3617-3622.
doi:10.1016/0277-5387(96)00081-2

[10]. Losada, J.; Peso, D. I.; Beyer, L. Trans. Metal Chem., 2000, 25, 112-115.
doi:10.1023/A:1007030327569

[11]. Saeed, S.; Rashid, N.; Hussain, R.; Ali, M.; Jones, P. G. Eur. J. Med. Chem. 2010, 45, 1323-1331.
doi:10.1016/j.ejmech.2009.12.016
PMid:20056520

[12]. Saeed, S.; Rashid, N; Jones, P. G.; Hussain, R.; Bhatti, M. H. Cent. Eur. J. Chem. 2010, 8(3), 550-558.
doi:10.2478/s11532-010-0014-2

[13]. Saeed, S.; Rashid, N; Jones, P. G.; Yunus, U. J. Heterocycl. Chem. 2010, 47, 908-912.
doi:10.1002/jhet.439

[14]. Eweis, M.; Elkholy, S. S.; Elsabee, M. Z. Int. J. Biol. Macromol. 2006, 38, 1-8.
doi:10.1016/j.ijbiomac.2005.12.009
PMid:16413607

[15]. Lachkova, V.; Varbanov, S.; Hagele, G.; Keck, H.; Tosheva, T. Phosphorus. Sulfur Silicon Relat. Elem. 2002, 177, 1303-1313.
doi:10.1080/10426500211707

[16]. Avsar, G.; Arslan, H.; Haupt, J.; Külcü, N. Turk. J. Chem. 2003, 27, 281-285.

[17]. Libe, F.; Philip, U. C. Miscellaneous structures of New Herbicides, Chem. Plant Prot. 1994, 10, 189-216.

[18]. Ru, C.; Wang, Y.; Li, J.; Ma, D.; Gong, F.; Liu, Y.; Lu. P. Yingyong Huaxue 1994, 11, 82-85.

[19]. Che, D. J.; Li, G.; Yao, X. L.; Wang, Q. J. W. L.; Zhu, Y. J. Organomet. Chem. 1999, 584, 190-195.
doi:10.1016/S0022-328X(99)00138-2

[20]. Che, D. J.; Yao, X. L.; Li, G.; Li, Y. H. J. Chem. Soc., Dalton Trans. 1998, 11, 1853-1856.

[21]. Cernak, J.; Chomic, J.; Kutschy, P.; Svercinova, D.; Dzurilla, M. Inorg. Chim. Acta 1991, 181, 85-92.
doi:10.1016/S0020-1693(00)85264-0

[22]. Hernandez, W.; Spodine, E.; Munoz, J. C.;Beyer, L.; Schroder, U.; Ferreira, J.; Pavani, M. Bioinorg. Chem. Appl. 2003, 1(3-4), 271-284.
doi:10.1155/S1565363303000219
PMid:18365059 PMCid:2267062

[23]. Hernandez, W.; Spodine, E.; Beyer, L.; Schroder, U.; Richter, R.; Ferreira, J.; Pavani, M. Bioinorg. Chem. Appl .2005, 3(3-4), 299-316.
doi:10.1155/BCA.2005.299
PMid:18365106 PMCid:2267103

[24]. Sheldrick, G. M. Acta Cryst. 2008, A64, 112-122.

[25]. Safin, D. A.; Bolte, M.; Babashkina, M. G. Trans. Metal Chem. 2009, 34, 43-49.
doi:10.1007/s11243-008-9157-9

[26]. National Committee for Clinical Laboratory Standards, M7-A4 (NCCLS, Viallanova, PA, USA, 1997).

[27]. National Committee for Clinical Laboratory Standards, M27-A2 (NCCLS, Wayne, PA, USA, 2002).

[28]. Wei, T. B.; Chen, J. C.; Wang, X. C. Synth. Commun. 1996, 26, 1147-1152.
doi:10.1080/00397919608003507

[29]. Illi, V. O. Tetrahedron Lett. 1979, 20, 2431-2435.
doi:10.1016/S0040-4039(01)86311-5

[30]. Mansuroglu, D. S.; Arslan, H.; Derveer, D. V.; Binzet, G. Phosphorus. Sulfur Silicon Relat. Elem. 2009, 184, 3221-3230.
doi:10.1080/10426500902979743

[31]. Arslan, H.; Mansuroglu, D. S.; Derveer, D. V.; Binzet, G. Spectrochim. Acta A 2009, 72, 561-571.
doi:10.1016/j.saa.2008.10.049
PMid:19097820

[32]. Mikami, M.; Nakagawa, I.; Shimanouch, T. Spectrochim. Acta A, 1967, 23, 1037-1042.
doi:10.1016/0584-8539(67)80027-8

[33]. Binzet, G.; Arslan, H.; Flörke, U.; Külcü, N. J. Coord. Chem. 2006, 59, 1395-1406.
doi:10.1080/00958970500512633

[34]. Allen, F. H. Acta Cryst. 2002, B58, 380-388.

[35]. Arslan, H.; Duran, N.; Borekci, G.; Ozer, C. K.; Akbay, C. Molecules, 2009, 14, 519-527.
doi:10.3390/molecules14010519

Supporting Agencies

Most read articles by the same author(s)

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).

Article Sidebar

Main Article Content

Abstract

Article Details

Most read articles by the same author(s)

Downloads

Metrics