Synthesis, characterization and antibacterial activity of nickel (II) and        copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide

Sohail Saeed; Naghmana Rashid; Muhammad Ali; Rizwan Hussain

doi:10.5155/eurjchem.1.3.200-205.120

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Published: Sep 29, 2010

DOI: https://doi.org/10.5155/eurjchem.1.3.200-205.120

Keywords:

Thiourea derivatives, Transition metal complexes, X-ray structure determination, Phase-transfer catalyst, Antibacterial activity

Section

Research Article

Issue

Vol. 1 No. 3 (2010): September 2010

Dates

Received 2010-05-21
Accepted 2010-07-22
Published 2010-09-29

Sohail Saeed

Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, 44000, Pakistan

Naghmana Rashid

Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, 44000, Pakistan

Muhammad Ali

Department of Pharmacy, University of The Punjab, Lahore, 54590, Pakistan

Rizwan Hussain

National Engineering & Scientific Commission, P.O. Box 2801, Islamabad, Pakistan

Abstract

Nickel and copper metal complexes of N-(R-carbamothioyl)-4-nitrobenzamide (R = diphenyl and ethylbutyl) were synthesized and characterized by IR, ¹H NMR, mass spectrometry and elemental analysis. The spectroscopic data are consistent with the ligand and the metal complexes containing two O and S chelated ligands. N-(diphenylcarbamothioyl)-4-nitrobenzamide, HL¹, was characterized by a single crystal X-ray diffraction study. It crystallizes in the triclinic space group P with unit cell dimensions of a = 6.8044(4) Å, b = 10.0113(6) Å, c = 13.2365(8) Å, α = 6.8044(4) °, β = 78.171(4) °, γ = 13.2365(8)°, V = 882.43(9) Å³. The ligands coordinate as bidentates yielding essentially neutral complexes of the type [ML₂]. The ligands and complexes were screened for their in vitro antibacterial activities and comparatively the complexes showed greater antibacterial efficacy than the thiourea derivative ligands.

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Saeed, S.; Rashid, N.; Ali, M.; Hussain, R. Synthesis, Characterization and Antibacterial Activity of Nickel (II) and Copper (II) Complexes of N-(alkyl(aryl)carbamothioyl)-4-Nitrobenzamide. Eur. J. Chem. 2010, 1, 200-205.

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