European Journal of Chemistry

Synthesis of some novel benzimidazole derivatives and their biological evaluation



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Dnyandev Radhu Gund
Balivada Venkata Satyasai Varaprasad Rao
Pandurang Narayanrao Mandhare
Sanjay Dashrath Vaidya

Abstract

A series of novel benzimidazole derivatives have been synthesized by the condensation of o-phenylenediamine with 4-bromophenoxy acetic acid and product obtained was alkylated at the benzimidazole -NH with different electrophilic reagents. Subsequent reactions of the products by the Suzuki Coupling between benzimidazole derivatives and phenylboronic acid derivatives were accomplished. All these compounds were characterized by FT-IR, 1H NMR, MS and elemental analysis. These compounds were screened for their potential antibacterial and antifungal activities. This exhibited some promising results towards testing organism in-vitro.


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Gund, D. R.; Rao, B. V. S. V.; Mandhare, P. N.; Vaidya, S. D. Synthesis of Some Novel Benzimidazole Derivatives and Their Biological Evaluation. Eur. J. Chem. 2015, 6, 270-274.

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