European Journal of Chemistry

Synthesis and antimicrobial activity of some novel N-substituted benzimidazoles



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Dnyandev Radhu Gund
Alok Pramod Tripathi
Sanjay Dashrath Vaidya

Abstract

Synthesis of a series of new substituted benzimidazole derivatives by the condensation of     o-phenylenediamine with urea to give 1,3-dihydro-benzimidazol-2-one which reacted with phosphoryl chloride to give 2-chloro-1H-benzimidazole is reported. The product was then alkylated at the benzimidazole NH with different electrophilic reagents leading to functionalized derivatives. Structures of the newly synthesized products have been deduced on the basis of spectral and analytical data. The synthesized compounds were screened for their antimicrobial activity. This exhibited some promising results towards testing organism in-vitro.


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Gund, D. R.; Tripathi, A. P.; Vaidya, S. D. Synthesis and Antimicrobial Activity of Some Novel N-Substituted Benzimidazoles. Eur. J. Chem. 2017, 8, 149-154.

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