European Journal of Chemistry

Synthesis and antimicrobial activity of some novel N-substituted benzimidazoles

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Published: Jun 30, 2017
DOI: https://doi.org/10.5155/eurjchem.8.2.149-154.1563
Keywords:
Alkylation, Benzoylation, Benzimidazole, Antifungal activity, Antibacterial activity, Condensation reaction
Section
Research Article
Issue
Vol. 8 No. 2 (2017): June 2017
Dates
Received 2017-03-08
Accepted 2017-04-09
Published 2017-06-30


Main Article Content

Dnyandev Radhu Gund
Department of Chemistry, Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, 333001, India
Alok Pramod Tripathi
Department of Chemistry, Rajasthan University, Jaipur 302004, India
Sanjay Dashrath Vaidya
Department of Chemistry, Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, 333001, India

Abstract

Synthesis of a series of new substituted benzimidazole derivatives by the condensation of     o-phenylenediamine with urea to give 1,3-dihydro-benzimidazol-2-one which reacted with phosphoryl chloride to give 2-chloro-1H-benzimidazole is reported. The product was then alkylated at the benzimidazole NH with different electrophilic reagents leading to functionalized derivatives. Structures of the newly synthesized products have been deduced on the basis of spectral and analytical data. The synthesized compounds were screened for their antimicrobial activity. This exhibited some promising results towards testing organism in-vitro.


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Gund, D. R.; Tripathi, A. P.; Vaidya, S. D. Synthesis and Antimicrobial Activity of Some Novel N-Substituted Benzimidazoles. Eur. J. Chem. 2017, 8, 149-154.

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Supporting Agencies

Sophisticated Analytical Instrumentation Facility, Punjab University and Microcare laboratories, Surat, India
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