Solvatochromic absorption and fluorescence studies of adenine, thymine and uracil thio-derived acyclonucleosides

Hassan Hasan Hammud; Mohammad Hasan El-Dakdouki; Nada Mohamd Sonji; Kamal Hani Bouhadir

doi:10.5155/eurjchem.6.3.325-336.1282

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Published: Sep 30, 2015

DOI: https://doi.org/10.5155/eurjchem.6.3.325-336.1282

Keywords:

Absorption, Nucleobases, Fluorescence, Solvatochromism, Multiple regression analysis, Thio-derived acyclonucleosides

Section

Research Article

Issue

Vol. 6 No. 3 (2015): September 2015

Dates

Received 2015-06-09
Accepted 2015-07-15
Published 2015-09-30

Hassan Hasan Hammud

Department of Chemistry, Faculty of Science, King Faisal University, Al-Ahsa, 31982, Saudi Arabia

Mohammad Hasan El-Dakdouki

Department of Chemistry, Faculty of Science, Beirut Arab University, Debbieh, 11-5020, Lebanon

Nada Mohamd Sonji

Department of Chemistry, Faculty of Science, Beirut Arab University, Debbieh, 11-5020, Lebanon

Kamal Hani Bouhadir

Department of Chemistry, Faculty of Arts and Sciences, American University of Beirut, Beirut, 11-0236, Lebanon

Abstract

Adenine, thymine and uracil thio-derived acyclonucleosides were synthesized and characterized by UV-Vis, FT-IR, ¹H and ¹³C NMR spectroscopic techniques. The photophysical properties of the derivatives were evaluated in solvents with diverse polarities and at various pH values. The solvent dependent absorbance and emission spectral shifts were analysed using physical parameters of the selected solvents. The regression and correlation coefficients were calculated using multiple regression techniques. The fitting coefficients gave an estimate of the contribution of each interaction to the total spectral shift in various solutions. Multiple linear regression studies, Kamlet-Taft equation and stokes shift correlation with orientation polarizability provide valuable information concerning spectroscopic characteristics of the studied molecules.

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(1)

Hammud, H. H.; El-Dakdouki, M. H.; Sonji, N. M.; Bouhadir, K. H. Solvatochromic Absorption and Fluorescence Studies of Adenine, Thymine and Uracil Thio-Derived Acyclonucleosides. Eur. J. Chem. 2015, 6, 325-336.

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Supporting Agencies

Kamal Shair Central Research Science Laboratory (KAS-CRSL), Lebanese National Research Council (LNCSR) and the University Research Board (URB) at the American University of Beirut, Lebanon

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