

Determination of dimenhydrinate and cinnarizine in combined dosage form in presence of cinnarizine impurity
Nada Sayed Abdelwahab (1)




(1) Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni‐Suef, 62514 Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni‐Suef, 62514 Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, El-Azhar University, Cairo, 11651, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Nahda University, Beni‐Suef, 62514 Egypt
(*) Corresponding Author
Received: 15 Sep 2015 | Accepted: 18 Oct 2015 | Published: 31 Dec 2015 | Issue Date: December 2015
Abstract
Three accurate, sensitive and time saving spectrophotometric methods have been developed and validated for determination of mixture of dimenhydrinate (DMH) and cinnarizine (CIN) in presence of cinnarizine impurity (1-(diphenylmethyl)piperazine) (IMP). In method A; dimenhydrinate was determined by measuring 1D amplitudes at 292.0 nm while cinnarizine and its impurity were determined by 1DD method at 256.2 and 219.6 nm, respectively, using standard spectrum of 20 µg/mL of dimenhydrinate as a divisor. Method B depends on dividing spectrum of ternary mixture by standard spectrum of 20 µg/mL of dimenhydrinate and then cinnarizine and its impurity were determined in the obtained ratio spectrum by ratio difference method using the difference between 219.0 and 237.2 nm and between 230.0 and 264.0 nm, respectively. On the other hand dimenhydrinate could be determined by dividing spectrum of ternary mixture by standard spectrum of 20 µg/mL of cinnarizine and then it were determined at the obtained ratio spectrum by ratio difference method using the difference between 216.8 and 232.8 nm. Method C is the mean cantering of ratio spectra method (MCR) where the amplitudes at 234.8, 240.0 and 233.6 nm in the second mean centering ratio spectra were used for determination of dimenhydrinate, cinnarizine and its impurity, respectively. The developed methods were validated according to ICH guidelines regarding good accuracy and precision, and they were successfully applied to pharmaceutical formulation and laboratory prepared mixtures. The results were statistically compared with those obtained by reported method and no significant difference was found.
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DOI: 10.5155/eurjchem.6.4.475-481.1324
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Citations
[1]. Mahmoud A. Mohamed, Mohamed El-Kassem M. Hassouna
Ecofriendly Spectrophotometric and Chromatographic Methods for Simultaneous Analysis of a Quaternary Mixture of Cephalexin, Sodium Benzoate, Methylparaben and Propylparaben with Application of the Holding Time Study in Bulk and Pharmaceutical Dosage Forms
Pharmaceutical Chemistry Journal 57(1), 146, 2023
DOI: 10.1007/s11094-023-02862-9

[2]. Nada S. Abdelwahab, Fadwa H. Edrees, Mohammed T. Alsaadi, Noha H. Amin, Ahmed S. Saad
Simultaneous estimation of dimenhydrinate, cinnarizine and their toxic impurities benzophenone and diphenylmethylpiperazine; in silico toxicity profiling of impurities
RSC Advances 10(61), 37439, 2020
DOI: 10.1039/D0RA06147F

[3]. S. Mullangi, K. Ravindhranath, M.R. Yarala, R.K. Panchakarla
A sensitive LC-MS/MS method for the determination of potential genotoxic impurities in Cinnarizine
Annales Pharmaceutiques Françaises 81(1), 74, 2023
DOI: 10.1016/j.pharma.2022.06.010

[4]. Nesrine T. Lamie, Hany H. Monir
Diode Array Detection for UPLC Determination of Cinnarizine and Dimenhydrinate in their Combined Dosage Form
Current Chromatography 7(2), 101, 2020
DOI: 10.2174/2213240607999200611154615

[5]. Ola M El-Houssini, Mohammad A Mohammad
Simple Eco-Friendly RP-LC Method for the Synchronous Separation of Six Widely Used Drugs in the Treatment of Cerebrovascular and Vestibular Disorders: Application for Analysis in Their Single and Combined Drug Products
Journal of AOAC INTERNATIONAL 105(4), 957, 2022
DOI: 10.1093/jaoacint/qsac021

[6]. Fadwa H. Edrees, Ahmed S. Saad, Mohammed T. Alsaadi, Noha H. Amin, Nada S. Abdelwahab
Experimentally designed chromatographic method for the simultaneous analysis of dimenhydrinate, cinnarizine and their toxic impurities
RSC Advances 11(3), 1450, 2021
DOI: 10.1039/D0RA09585K

[7]. Ola M El-Houssini, Mohammad A Mohammad
Versatile TLC-Densitometric Methods for the Synchronous Estimation of Cinnarizine and Acefylline Heptaminol in The Presence of Potential Impurity and Their Reported Degradation Products
Journal of Chromatographic Science 60(9), 832, 2022
DOI: 10.1093/chromsci/bmab129

[8]. Ola Mohamed EL-Houssini, Nagwan Hamdi Zawilla, Mohammad Abdul-Azim Mohammad
Validated RP-LC Methods for Investigating the Degradation Behavior of Acefylline: Application for Analysis in Two Binary Mixtures
Current Pharmaceutical Analysis 17(6), 801, 2021
DOI: 10.2174/1573412916999200423102505

[9]. Nehal Fayek Farid, Nada Sayed Abdelwahab
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European Journal of Chemistry 7(3), 329, 2016
DOI: 10.5155/eurjchem.7.3.329-333.1463

[10]. Deepak Krishna Mhaske, Arjun Shankar Kumbhar
The New RP-HPLC Method for Simultaneous Quantification of Cinnarizine, its Five Specified Impurities, Two Degradation Products with Two Antioxidants and Confirmation of all by HPLC-ESI-MS in Different Pharmaceutical Drug Formulations
Analytical Chemistry Letters 12(3), 391, 2022
DOI: 10.1080/22297928.2022.2067006

[11]. Shereen M. Tawakkol, Mohamed B. El-Zeiny, A. Hemdan
Full spectrum and selected spectrum based chemometric methods for the simultaneous determination of Cinnarizine and Dimenhydrinate in laboratory prepared mixtures and pharmaceutical dosage form
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 173, 892, 2017
DOI: 10.1016/j.saa.2016.10.055

References
[1]. Budavaried, S. The Merck Index: An encyclopedia of chemicals, drugs and biological, 40th Ed., Merck & Co., Inc., Whitehouse Station, NJ, USA, 2006.
[2]. Profitt, K. Martindale, The extra Pharmacopeia: The complete drug reference, 35th Ed., Royal Pharmaceutical Society, London, UK, 2006.
[3]. British Pharmacopoeia, Vol. II, Stationary Office, Medicines and Health care Products Regulatory Agency, London, UK, 2010.
[4]. European Pharmacopoeia, 6th Edi., European Department for the Quality of Medicines within the Council of Europe, Strasbourg, France, 2008
[5]. The United States Pharmacopoeia, 32th revision, NF 27, The United States Pharmacopoeial Convention Inc., Rockville, MD, 2009.
[6]. Shah, P.B.; Patel, P. U. J. Pharm. Sci. Bio-Sci. Res. 2012, 2(2), 83-87.
[7]. Dalwadi, N.; Chhalotiya, U. K.; Shah, D.; Mehta, F.; Bhatt, K. Int. J. Adv. Pharm. Anal. 2014, 4(2), 58-61.
[8]. Patel, A. P.; Kadikar, H. K.; Shah, R. R.; Shukla, M. H.; Tank, P. K. Pharma Sci. Mon. Int. J. Pharm. Sci. 2012, 3(4), 2493-2505.
[9]. Lamie, N. T. Spectrochim. Acta A 2015, 141, 193-201.
http://dx.doi.org/10.1016/j.saa.2015.01.033
[10]. El-Kafrawy, D. S.; Belal, T. S. J. Assoc. Arab Univ. Basic Appl. Sci. 2014, doi:10.1016/j.jaubas.2014.06.004.
http://dx.doi.org/10.1016/j.jaubas.2014.06.004
[11]. Khushbu, S.; Pinkal, P. Int. J. Pharm. Sci. Res. 2014, 5(11), 4815-4819.
[12]. Lamie, N. T.; Monir, H. H. J. Chromatogr. Sci. 2015, doi:10.1093/chromsci/bmv103
http://dx.doi.org/10.1093/chromsci/bmv103
[13]. International conference on the harmonization of technical requirements for the registration of pharmaceuticals for human use (ICH) Q2 (R1) Validation of Analytical Procedures: Text and Methodology. ICH Harmonized Tripartite Guideline, 2005.
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DOI Link: https://doi.org/10.5155/eurjchem.6.4.475-481.1324

















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