European Journal of Chemistry

Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro

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Published: Mar 31, 2016
DOI: https://doi.org/10.5155/eurjchem.7.1.102-106.1374
Keywords:
Synthesis, Schiff base, Sulfonamide, Metal complexes, Modeling studies, Antimicrobial activity
Section
Research Article
Issue
Vol. 7 No. 1 (2016): March 2016
Dates
Received 2015-11-26
Accepted 2016-01-02
Published 2016-03-31


Main Article Content

Wasfi Aboud Al-Masoudi
Department of Physiology and Chemistry, College of Veterinary, University of Basrah, Basrah 61001, Iraq
Rana Adnan Faaz
Department of Microbiology, College of Veterinary, University of Basrah, Basrah 61001, Iraq
Rafid Hmedan Al-Asadi
Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah 61001, Iraq
Hazim Saad Jabbar
Department of Basic Sciences, College of Dentistry, University of Basrah, Basrah 61001, Iraq

Abstract

Palladium(II) and cobalt(II) complexes of Schiff base derived from 4-aminobenzene sulfonamide (Sulfonamide drug) were prepared by convenient method. Reaction of sulfonamide with 2-hydroxy-1-naphthaldehyde gave the Schiff base compound 1 in good yield. Treatment of compound 1 with CoCl2.6H2O and PdCl2yielded new metal complexes 2 and 3, respectively. The synthesized compounds were screened for their antibacterial activity against Escherichia coli, Bacillus cereus, Salmonella spp. and Staphylococcus aureus. Additionally, the compounds were tested for antifungal activity against Aspergillus niger and Candida albicans. Some compounds exhibited good antibacterial and antifungal activity. Molecular modeling studies were performed and showed hydrogen binding and hydrophobic interactions.


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Al-Masoudi, W. A.; Faaz, R. A.; Al-Asadi, R. H.; Jabbar, H. S. Synthesis, Antimicrobial Activity and Modelling Studies of Some New Metal Complexes of Schiff Base Derived from Sulphonamide Drug in Vitro. Eur. J. Chem. 2016, 7, 102-106.

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Departments of Physiology and Microbiology, College of Veterinary Medicine, Basrah University, Iraq
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