European Journal of Chemistry

Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro

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Wasfi Aboud Al-Masoudi
Rana Adnan Faaz
Rafid Hmedan Al-Asadi
Hazim Saad Jabbar


Palladium(II) and cobalt(II) complexes of Schiff base derived from 4-aminobenzene sulfonamide (Sulfonamide drug) were prepared by convenient method. Reaction of sulfonamide with 2-hydroxy-1-naphthaldehyde gave the Schiff base compound 1 in good yield. Treatment of compound 1 with CoCl2.6H2O and PdCl2yielded new metal complexes 2 and 3, respectively. The synthesized compounds were screened for their antibacterial activity against Escherichia coli, Bacillus cereus, Salmonella spp. and Staphylococcus aureus. Additionally, the compounds were tested for antifungal activity against Aspergillus niger and Candida albicans. Some compounds exhibited good antibacterial and antifungal activity. Molecular modeling studies were performed and showed hydrogen binding and hydrophobic interactions.

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Al-Masoudi, W. A.; Faaz, R. A.; Al-Asadi, R. H.; Jabbar, H. S. Synthesis, Antimicrobial Activity and Modelling Studies of Some New Metal Complexes of Schiff Base Derived from Sulphonamide Drug in Vitro. Eur. J. Chem. 2016, 7, 102-106.

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[1]. Robin, R. C.; Melissa, K. R.; Johanna, M. B.; Joshwa, C. S.; Scott, N. Trans. Metal Chem. 2005, 30, 411-418.

[2]. Shivakumar, K.; Shashidhar; Reddy, P. V.; Halli, M. B. J. Coord. Chem. 2008, 61(14), 2274-2287.

[3]. Shi, L.; Mao, W. J.; Yang, Y.; Zhu, H. L. J. Coord. Chem. 2009, 62(21), 3471-3477.

[4]. Gupta, M. K.; Har, L. S.; Varshney, S.; Vareshny, A. K. Bioinorg. Chem. Appl. 2003, 1(3-4), 309-320.

[5]. Hahn, R. C.; Moratoconciecao, Y. T.; Santos, N. L.; Ferreira, J. F.; Hamdan, J. S. Mycoses 2003, 46, 342-347.

[6]. Henry, R. J. Bacteriol. Rev. 1943, 7(4), 175-262.

[7]. Mohamed, G. G.; Carmen, M. S. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2007, 66, 949-958.

[8]. Rudzinski, W. E.; Aminabhavie, T. M.; Biradar, N. S.; Patil, C. S. Inorg. Chim. Acta. 1982, 67, 177-182.

[9]. Raveendran, R.; Pal, S. J. Organomet. Chem. 2007, 692(4), 824-830.

[10]. Orvig, C.; Abrams, M. J. Chem. Rev. 1999, 99, 2201-2203

[11]. Saha, N.; Muherjee, D. Inorg. Chem. Acta 1987, 137, 161-166.

[12]. Shah, S. N; Basser, M. A. Asian J. Pharm. Clin. Res. 2012, 5(3), 146-149.

[13]. Zhan, P.; Liu, X.; Li, Z.; Fang, Z.; Pannecouque, C.; De Clercq, E. Chem. Biodivers. 2010, 7, 1717-1727.

[14]. Onuffer, J. J.; Ton, B. T.; Kleent, I.; Kirsch, J. F. Protein Sci. 1995, 4, 1743-1749.

[15]. Seeliger, S.; de Groot, B. L. J. Computer-Aided Mol. Design 2010, 24, 417-422.

[16]. Al-Masoudi, W. A.; Mohmmed, A. L.; Abass, W. H.; Al-Masoudi, N. A. Eur. J. Chem. 2015, 6(2), 127-130.

Supporting Agencies

Departments of Physiology and Microbiology, College of Veterinary Medicine, Basrah University, Iraq

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