European Journal of Chemistry

Synthesis, characterization and acute toxicity of new Schiff base derived from phenylethyl amine and 2-hydroxy naphthaldehyde

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Published: Mar 31, 2019
DOI: https://doi.org/10.5155/eurjchem.10.1.26-29.1790
Keywords:
Schiff base, HSQC-NMR, Acute toxicity, IR spectroscopy, Phenylethylamine, 2-Hydroxy naphthaldehyde
Section
Research Article
Issue
Vol. 10 No. 1 (2019): March 2019
Dates
Received 2018-09-16
Accepted 2018-11-10
Published 2019-03-31
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Main Article Content

Ibtihal Hassan Hatim
Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
http://orcid.org/0000-0001-9721-6024
Wasfi Aboud Al-Masoudi
Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
http://orcid.org/0000-0002-5932-0311
Rashad Fadhil Ghadhban
Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
http://orcid.org/0000-0003-3518-6653

Abstract

There is an urgent need for the design and development of new and safer drugs, this has attracted organic chemists to synthesize new compounds with potential of biological and chemotherapeutic activities. Here we report, the condensation of phenylethylamine with 2-hydroxy naphthaldehyde yielded Schiff base derivative in good yield. Characterization of synthesized compound was carried by elemental analysis, IR, 1H-, 13C- and HSQC-NMR spectroscopy. The toxicity of the synthesized compound was determined using Balb/c mice model. Dixon’s up and down method was found to have an LD50 of 827.2 mg/kg of body weight, moderate toxicity.


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How to Cite
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Hatim, I. H.; Al-Masoudi, W. A.; Ghadhban, R. F. Synthesis, Characterization and Acute Toxicity of New Schiff Base Derived from Phenylethyl Amine and 2-Hydroxy Naphthaldehyde. Eur. J. Chem. 2019, 10, 26-29.

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Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, Al-Basrah University, Basrah, Iraq.
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