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Pharmacological evaluation of ONNO donor quadridentate Schiff bases
Muhammad Shabbir (1) , Zareen Akhter (2,*) , Ahmad Raza Ashraf (3) , Michael Bolte (4) , Sumbal Wahid (5) , Bushra Mirza (6)
(1) Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan
(2) Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan
(3) Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan
(4) Institut für Anorganische Chemie, Johann Wolfgang Goethe-Universität Frankfurt, Max-Von-Laue-Strasse 7, Frankfurt, Main 60438, Germany
(5) Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
(6) Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
(*) Corresponding Author
Received: 28 Dec 2016 | Revised: 09 Jan 2017 | Accepted: 21 Jan 2017 | Published: 31 Mar 2017 | Issue Date: March 2017
Four ONNO donor Schiff bases 2-((E)-(2-((E)-2-hydroxybenzylideneamino)ethylimino) methyl)phenol (H2L1), 2-((E)-(2-((E)-2-hydroxybenzylideneamino)propylimino)methyl) phenol (H2L2), 2-((E)-1-(2-((E)-1-(2-hydroxyphenyl) ethylideneamino)ethylimino)ethyl) phenol (H2L3) and 2-((E)-1-(2-((E)-1-(2-hydroxyphenyl)ethylideneamino)propylimino) ethyl)phenol (H2L4) were synthesized by the reactions of ethylene/propylene diamines with 2-hydroxy benzaldehyde/2-hydroxy acetophenone. The new compounds were characterized by FT-IR and NMR (1H and 13C) spectroscopic techniques accompanied by elemental, GC/MS and single crystal X-ray diffraction analyses. These compounds were screened for various biological studies i.e. brine shrimp cytotoxic, antitumor and antibacterial activities The compound H2L3 showed highest cytotoxic and antitumor activities with lowest LD50 (14.27) and IC50 values (18.90). All the compounds were highly active in protecting DNA against hydroxyl free radicals. Antibacterial studies had shown that these were inactive against Gram positive bacteria (Staphylococcus aureus and Micrococcus luteus) while active against Gram negative bacteria (Enterobacter aerogenes, Bordetella bronchiseptica and Salmonella typhi) showing variable antibacterial activity.
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DOI Link: https://doi.org/10.5155/eurjchem.8.1.46-51.1535
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