European Journal of Chemistry

Heteroaromatization with 4-phenyldiazenyl-1-naphthol. Part III: One-pot synthesis and DFT study of 4H-naphthopyran derivatives

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Published: Dec 31, 2017
DOI: https://doi.org/10.5155/eurjchem.8.4.358-366.1632
Keywords:
Malononitrile, Fukui functions, Ethyl cyanoacetate, 4-Phenyldiazenyl-1-naphthol, 4H-Naphthopyran derivatives, Density Functional Theory (DFT)
Section
Research Article
Issue
Vol. 8 No. 4 (2017): December 2017
Dates
Received 2017-07-21
Accepted 2017-09-04
Published 2017-12-31


Main Article Content

Hany Mostafa Mohamed
Chemistry Department, Faculty of Science, Jazan University, 2097, Jazan, Kingdom Saudi Arabia
Ashraf Hassan Fekry Abd El-Wahab
Chemistry Department, Faculty of Science, Jazan University, 2097, Jazan, Kingdom Saudi Arabia
Tarek Maamon El-Gogary
Chemistry Department, Faculty of Science (Domyat), Damietta University, 34517, Domyat Al-Gideda, Egypt

Abstract

A one pot three component reaction of 4-phenyldiazenyl-1-naphthol (1), p-chloro benzaldehyde (2) and malononitrile or ethyl cyanoacetate (3) in ethanol/piperidine under reflux afforded 2-amino-4-(p-chlorophenyl)-6-phenyldiazenyl-4H-naphtho[1,2-b]pyrano-3-carbonitrile (4a) and ethyl 2-amino-4-(p-chlorophenyl)-6-phenyldiazenyl-4H-naphtho[1,2-b]pyrano -3-carboxylate (4b). Structure of these compounds was established on the basis of IR, 1H NMR, 13C NMR, Mass and UV-Vis spectra. Molecular geometry of compounds 4a and b was obtained at B3LYP/6-31+G(d) level. Two tautomers and two conformers were geometrically optimized. The tautomers are separated by about 7.942 kcal/mol while rotational conformers are only separated by 0.511 kcal/mol. Molecular reactivity descriptors including global electrophilicity, hardness, softness and local condensed Fukui functions were computed and discussed. Frontier molecular orbitals (HOMO and LUMO) were also computed.


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Mohamed, H. M.; Abd El-Wahab, A. H. F.; El-Gogary, T. M. Heteroaromatization With 4-Phenyldiazenyl-1-Naphthol. Part III: One-Pot Synthesis and DFT Study of 4H-Naphthopyran Derivatives. Eur. J. Chem. 2017, 8, 358-366.

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Jazan University, 2097, Jazan, Kingdom Saudi Arabia.
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