European Journal of Chemistry 2019, 10(3), 209-217 | doi: https://doi.org/10.5155/eurjchem.10.3.209-217.1850 | Get rights and content

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Synthesis, reactions and biological evaluation of some novel thienothiophene derivatives


Mounir Abbas Ali Mohamed (1,*) orcid , Hanan Salah (2) orcid , Ahmed Mohamed Mohamed El-Saghier (3) orcid

(1) Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
(2) Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
(3) Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
(*) Corresponding Author

Received: 18 Mar 2019 | Revised: 26 May 2019 | Accepted: 28 May 2019 | Published: 30 Sep 2019 | Issue Date: September 2019

Abstract


Synthesis of some new bis(chalcones)-based thienothiophene derivatives and study of their synthetic utilities as building blocks for new bis(thiazole), bis(dihydropyran), bis(dihydro pyridine), bis(isoxazoles), bis(pyrazoles), bis(hydropyrimidinethiones), bis(tetrahydro diazepines, oxazepines) and bis(dihydrobenzodiazepnies, benzoxazepines) each linked to a thienothiophene core, is reported. Biological evaluation of the obtained compounds as antibacterial agents was achieved. Compounds 4b, 4c, 7a, 6a, 9a and 11b were found to be very potent against P. aeruginosa, E. coli and K. pneumonia.


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European Journal of Chemistry

Keywords


Chalcone; Isoxazole; Diazepine; Oxazepine; Thienothiophene; Antibacterial activity

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DOI: 10.5155/eurjchem.10.3.209-217.1850

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Funding information


Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

Citations

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[1]. Ayesha Rafiq, Sana Aslam, Matloob Ahmad, Muhammad Shahid Nazir, Ambar Farooq, Sadia Sultan
Recent synthetic approaches towards thienothiophenes: a potential template for biologically active compounds
Molecular Diversity  , , 2023
DOI: 10.1007/s11030-023-10647-1
/


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How to cite


Mohamed, M.; Salah, H.; El-Saghier, A. Eur. J. Chem. 2019, 10(3), 209-217. doi:10.5155/eurjchem.10.3.209-217.1850
Mohamed, M.; Salah, H.; El-Saghier, A. Synthesis, reactions and biological evaluation of some novel thienothiophene derivatives. Eur. J. Chem. 2019, 10(3), 209-217. doi:10.5155/eurjchem.10.3.209-217.1850
Mohamed, M., Salah, H., & El-Saghier, A. (2019). Synthesis, reactions and biological evaluation of some novel thienothiophene derivatives. European Journal of Chemistry, 10(3), 209-217. doi:10.5155/eurjchem.10.3.209-217.1850
Mohamed, Mounir, Hanan Salah, & Ahmed Mohamed Mohamed El-Saghier. "Synthesis, reactions and biological evaluation of some novel thienothiophene derivatives." European Journal of Chemistry [Online], 10.3 (2019): 209-217. Web. 24 Sep. 2023
Mohamed, Mounir, Salah, Hanan, AND El-Saghier, Ahmed. "Synthesis, reactions and biological evaluation of some novel thienothiophene derivatives" European Journal of Chemistry [Online], Volume 10 Number 3 (30 September 2019)

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