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Synthesis, reactions and biological evaluation of some novel thienothiophene derivatives
Mounir Abbas Ali Mohamed (1,*)
, Hanan Salah (2) , Ahmed Mohamed Mohamed El-Saghier (3) (1) Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
(2) Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
(3) Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
(*) Corresponding Author
Received: 18 Mar 2019 | Revised: 26 May 2019 | Accepted: 28 May 2019 | Published: 30 Sep 2019 | Issue Date: September 2019
Abstract
Synthesis of some new bis(chalcones)-based thienothiophene derivatives and study of their synthetic utilities as building blocks for new bis(thiazole), bis(dihydropyran), bis(dihydro pyridine), bis(isoxazoles), bis(pyrazoles), bis(hydropyrimidinethiones), bis(tetrahydro diazepines, oxazepines) and bis(dihydrobenzodiazepnies, benzoxazepines) each linked to a thienothiophene core, is reported. Biological evaluation of the obtained compounds as antibacterial agents was achieved. Compounds 4b, 4c, 7a, 6a, 9a and 11b were found to be very potent against P. aeruginosa, E. coli and K. pneumonia.
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DOI: 10.5155/eurjchem.10.3.209-217.1850
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Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
Citations
[1]. Ayesha Rafiq, Sana Aslam, Matloob Ahmad, Muhammad Shahid Nazir, Ambar Farooq, Sadia Sultan
Recent synthetic approaches towards thienothiophenes: a potential template for biologically active compounds
Molecular Diversity , , 2023
DOI: 10.1007/s11030-023-10647-1
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