European Journal of Chemistry

Synthesis, reactions and biological evaluation of some novel thienothiophene derivatives

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Mounir Abbas Ali Mohamed
Hanan Salah
Ahmed Mohamed Mohamed El-Saghier

Abstract

Synthesis of some new bis(chalcones)-based thienothiophene derivatives and study of their synthetic utilities as building blocks for new bis(thiazole), bis(dihydropyran), bis(dihydro pyridine), bis(isoxazoles), bis(pyrazoles), bis(hydropyrimidinethiones), bis(tetrahydro diazepines, oxazepines) and bis(dihydrobenzodiazepnies, benzoxazepines) each linked to a thienothiophene core, is reported. Biological evaluation of the obtained compounds as antibacterial agents was achieved. Compounds 4b, 4c, 7a, 6a, 9a and 11b were found to be very potent against P. aeruginosa, E. coli and K. pneumonia.


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Mohamed, M. A. A.; Salah, H.; El-Saghier, A. M. M. Synthesis, Reactions and Biological Evaluation of Some Novel Thienothiophene Derivatives. Eur. J. Chem. 2019, 10, 209-217.

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Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
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