European Journal of Chemistry

NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines


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Gajanan Gopinath Mandawad
Baseer Mubeen Shaikh
Santosh Subhash Chobe
Shankaraiah Guruvaiah Konda


A simple and eloquent procedure for the synthesis of a new series of thienyl benzo[b]1,4-diazepines is reported. They were synthesized by the condensation of o-phenylenediamine (o-PDA) with distinct hetero chalcones using NaOH in polyethylene glycol (PEG-400) as green and alternative reaction solvent. The significances of this present method are shorter reaction time, easy work-up, high yields, and mild reaction conditions. Furthermore, this method is environment friendly and without use of an expensive catalyst. The all newly synthesized compounds are characterized by the spectroscopic methods.

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Mandawad, G. G.; Shaikh, B. M.; Chobe, S. S.; Konda, S. G. NaOH/PEG-400:/An/Eloquent/System/for/the/Synthesis/of/New/Thienyl/benzo[b]1,4-Diazepines. Eur. J. Chem. 2020, 11, 276-279.

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[1]. Mallinath, M. L. Der Pharma Chem. 2011, 3(2), 273-276.

[2]. Konda, S. G.; Shaikh, B. M.; Chavan, S. A.; Dawane, B. S. Chinese Chem. Lett. 2011, 22, 65-68.

[3]. Naraboli, B. S.; Biradar, J. S. Int. J. Pharm. Pharm. Sci. 2017, 9(8), 128-138.

[4]. Sandra, C. M.; Eduardo, C. C.; Simon, H. O.; Teresa, R. A.; Antonio, N. C.; Lijanova, I. V. Med. Chem. 2012, 12(6), 611-618.

[5]. Henderson, E. A.; Alber, D. G.; Baxter, R. C.; Bithell, S. K.; Budworth, J.; Carter, M. C. J. Med. Chem. 2007, 50(7), 1685-1692.

[6]. Griffin, C. E.; Kaye, A. M.; Bueno, F. R.; Kaye, A. D. Ochsner. J. 2013, 13(2), 214-223.

[7]. Thakuria, H.; Pramanik, A.; Borah, B. M.; Das, G. Tetrahedron Lett. 2006, 47, 3135-3138.

[8]. Reddy, K. V. V.; Rao, P. S.; Ashok, D. Synth. Commun. 2000, 30, 1825-1836.

[9]. Gupta, R.; Kumar, M.; Gupta, V. Heterocyclic Chemistry of Five Membered Heterocycles, New York, 1999, 2. 416-426.

[10]. Herbert, J. A. L.; Suschitzky, H. J. Chem. Soc., Perkin Trans. 1974, 1, 2657-2661.

[11]. Morales, H. R.; Bulbarela, A. Heterocycles 1986, 24, 135-139.

[12]. Jung, D. I.; Choi, T. W.; Kim, Y. Y.; Kim, I. S.; Park, Y. M.; Lee, Y. G.; Jung, D. H. Synth. Commun. 1999, 29, 1941-1951.

[13]. Yadav, J. S.; Reddy, B. V. S.; Eshwaraian, B.; Anuradha, K. Green Chem. 2002, 4, 592-594.

[14]. Curini, M.; Epifano, F.; Marcotullio, M. C.; Rosati, O. Tetrahedron Lett. 2001, 42, 3193-3195.

[15]. Balakrishna, M. S.; Kaboundin, B. Tetrahedron Lett. 2001, 42, 1127-1129.

[16]. Pozarentzi, M.; Stephanidou, S. J. Tetrahedron Lett. 2002, 43, 1755-1758.

[17]. Ma, Y.; Zhang, Y. Synth. Commun. 2002, 32, 163-166.

[18]. Jarikote, D. V.; Siddique, S. A.; Rajagopal, R.; Daniel, T.; Lahoti, R. J.; Srinivasan, K. V. Tetrahedron Lett. 2003, 44, 1835-1838.

[19]. Kodomari, M.; Noguchi, T.; Aoyama, T. Synth. Commun. 2004, 34, 1783-1790.

[20]. Sabitha, G. S.; Reddy, K. K.; Reddy, K. B.; Reddy, N. M.; Yadav, J. S. Adv. Synth. Catal. 2004, 346, 921-923.

[21]. Reddy, B. M.; Sreekanth, P. M.; Reddy, V. R. J. Mol. Cat A 2005, 225, 71-78.

[22]. Kaboudin, B.; Navaee, K. Heterocycles 2001, 55(8), 1443-1446.

[23]. Yadav, J. S.; Reddy, B. V. S.; Praveenkumar, S.; Nagaiah, K.; Lingaiah, N.; Saiprasad, P. S. Synthesis 2004, 6, 901-904.

[24]. Chari, M. A.; Syamasundar, K. Cat. Commun. 2005, 6(1), 67-70.

[25]. Hegedus, A.; Hell, Z.; Potor, A. Cat. Lett. 2005, 105, 229-232.

[26]. Chen, J.; Spear, S. K.; Huddieston, J. G.; Rogers, R. D. Green Chem. 2005, 7, 64-82.

[27]. Heldebrant, D.; Jessop, P. G. J. Am. Chem. Soc. 2003, 125, 5600-5601.

[28]. Chandrasekhar, S.; Narsihmulu, Ch.; Sultana, S. S.; Reddy, N. R. K. Org. Lett. 2002, 4, 4383-4399.

[29]. Jiang, R.; Kuang, Y. Q.; Sun, X. L.; Zhang, S. Y. Tetrahedron Asym. 2004, 15, 743-746.

[30]. Namboodiri, V. V.; Varma, R. S. Green Chem. 2001, 3, 146-148.

[31]. Suryakiran, N.; Ramesh, D.; Venkateswarulu, Y. Green Chem. Lett. 2007, 1, 73-78.

[32]. Kamal, A.; Reddy, D. R.; Rajendar, S. Tetrahedron Lett. 2005, 46, 7951-7953.

[33]. Kamble, V. T.; Dawane, B. S.; Chavan, S. A.; Bhosale, R. B. Aust. J. Chem. 2007, 60, 302-304.

[34]. Das, B.; Krishnaiah, M.; Balasybramanyam, P.; Veeranjaneyulu, B.; Nanda, K. D. Tetrahedron Lett. 2008, 49, 2225-2227.

[35]. Konda, S. G.; Humne, V. T.; Lokhande, P. D. Green Chem. 2011, 13, 2354-2358.

[36]. Dawane, B. S.; Konda, S. G.; Bhosale, R. B.; Shaikh, B. M. Acta. Pharm. 2009, 59, 473-482.

[37]. Dawane, B. S.; Konda, S. G.; Mandawad, G. G.; Shaikh, B. M. Eur. J. Med. Chem. 2010, 45, 387-392.

[38]. Konda, S. G. Eur. J. Chem. 2014, 5(4), 676-680.

[39]. Konda, S. G. J. Adv. Chem. Sci. 2016, 2(3), 363-365.

[40]. Mandawad, G. G.; Chobe, S. S.; Yemul, O. S.; Dawane, B. S. J. Pharm Res. 2011, 4(10), 3360-3363.

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