European Journal of Chemistry

A novel and efficient approach for the synthesis of new halo substituted 2-arylpyrazolo[4,3-c] coumarin derivatives

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Published: Jun 30, 2011
DOI: https://doi.org/10.5155/eurjchem.2.2.223-228.336
Keywords:
Iodine, Lactonisation, Deallylation, 2-Arylpyrazolo[4, 3-c]coumarins, Oxidation, Iodination
Section
Research Article
Issue
Vol. 2 No. 2 (2011): June 2011
Dates
Received 2010-11-21
Accepted 2011-02-17
Published 2011-06-30


Main Article Content

Pradeep Lokhande
Department of Chemistry, Organic Research Chemistry, University of Pune, Pune-411007, India
Kamal Hasanzadeh
Department of Chemistry, Organic Research Chemistry, University of Pune, Pune-411007, India
Shankaraiah Guruvaiah Konda
Department of Chemistry, Organic Research Chemistry, University of Pune, Pune-411007, India

Abstract

A convenient protocol for the efficient synthesis of 2-arylpyrazolo[4,3-c]coumarins is described. The synthesis route involves molecular iodine catalyzed oxidative cyclization of 1-phenyl-3-(2'-hydroxyaryl)-4-formyl pyrazoles in dimethylsulfoxide. During the lactonisation of 4-formylpyrazoles, we found that iodine was incorporated into the unsubstituted O/P position of the 3-(2'-hydroxyaryl) group. Under similar conditions o-allyloxy derivative of pyrazoles gave same corresponding lactone derivatives by deallylation, lactonisation, and iodination in one step.

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Lokhande, P.; Hasanzadeh, K.; Konda, S. G. A Novel and Efficient Approach for the Synthesis of New Halo Substituted 2-arylpyrazolo[4,3-C] Coumarin Derivatives. Eur. J. Chem. 2011, 2, 223-228.

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