European Journal of Chemistry

A novel and efficient approach for the synthesis of new halo substituted 2-arylpyrazolo[4,3-c] coumarin derivatives

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Pradeep Lokhande
Kamal Hasanzadeh
Shankaraiah Guruvaiah Konda


A convenient protocol for the efficient synthesis of 2-arylpyrazolo[4,3-c]coumarins is described. The synthesis route involves molecular iodine catalyzed oxidative cyclization of 1-phenyl-3-(2'-hydroxyaryl)-4-formyl pyrazoles in dimethylsulfoxide. During the lactonisation of 4-formylpyrazoles, we found that iodine was incorporated into the unsubstituted O/P position of the 3-(2'-hydroxyaryl) group. Under similar conditions o-allyloxy derivative of pyrazoles gave same corresponding lactone derivatives by deallylation, lactonisation, and iodination in one step.


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Lokhande, P.; Hasanzadeh, K.; Konda, S. G. A Novel and Efficient Approach for the Synthesis of New Halo Substituted 2-arylpyrazolo[4,3-C] Coumarin Derivatives. Eur. J. Chem. 2011, 2, 223-228.

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