European Journal of Chemistry 2022, 13(2), 214-223 | doi: https://doi.org/10.5155/eurjchem.13.2.214-223.2236 | Get rights and content

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Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: Application to combined antibiotic formulations


Hind Ali Abdullatif (1) orcid , Adel Magdy Michael (2,*) orcid , Yossra Ahmed Trabik (3) orcid , Miriam Farid Ayad (4) orcid

(1) Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ahram Canadian University, Cairo,12573, Egypt
(2) Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ahram Canadian University, Cairo,12573, Egypt
(3) Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Ain Shams University, Cairo, 11571, Egypt
(4) Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Ain Shams University, Cairo, 11571, Egypt
(*) Corresponding Author

Received: 03 Mar 2022 | Revised: 11 Apr 2022 | Accepted: 29 Apr 2022 | Published: 30 Jun 2022 | Issue Date: June 2022

Abstract


This work describes a comparative study of two multivariate chemometric and univariate spectrophotometric methods for the determination of a ternary drug mixture containing oxytetracycline HCl, bromhexine HCl, and lidocaine HCl. All methods show high sensitivity and similar linearity range. Meanwhile, the chemometric method has the advantage of higher accuracy, higher specificity and better regression parameters. The two spectrophotometric methods are constant multiplication coupled with spectrum subtraction and successive ratio subtraction coupled with spectrum subtraction while the chemometric method used partial least square and principal component regression models. In addition, a spiking technique was used to increase the concentration of bromhexine HCl in the dosage form, allowing its determination despite its low contribution. Methods were successfully applied in the dosage form Oxyclear® veterinary injection in pure powder as well as in its pharmaceutical formulation. Statistical comparison showed no significant difference between the developed methods and the reference method.


Keywords


Chemometric; Lidocaine HCl; Bromhexine HCl; Oxytetracycline HCl; Veterinary formulation; Spectrophotometric method

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DOI: 10.5155/eurjchem.13.2.214-223.2236

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How to cite


Abdullatif, H.; Michael, A.; Trabik, Y.; Ayad, M. Eur. J. Chem. 2022, 13(2), 214-223. doi:10.5155/eurjchem.13.2.214-223.2236
Abdullatif, H.; Michael, A.; Trabik, Y.; Ayad, M. Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: Application to combined antibiotic formulations. Eur. J. Chem. 2022, 13(2), 214-223. doi:10.5155/eurjchem.13.2.214-223.2236
Abdullatif, H., Michael, A., Trabik, Y., & Ayad, M. (2022). Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: Application to combined antibiotic formulations. European Journal of Chemistry, 13(2), 214-223. doi:10.5155/eurjchem.13.2.214-223.2236
Abdullatif, Hind, Adel Magdy Michael, Yossra Ahmed Trabik, & Miriam Farid Ayad. "Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: Application to combined antibiotic formulations." European Journal of Chemistry [Online], 13.2 (2022): 214-223. Web. 19 Aug. 2022
Abdullatif, Hind, Michael, Adel, Trabik, Yossra, AND Ayad, Miriam. "Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: Application to combined antibiotic formulations" European Journal of Chemistry [Online], Volume 13 Number 2 (30 June 2022)

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