European Journal of Chemistry

Exploring DNA-interaction and molecular structure of ruthenium/1,2-bis-(diphenylphosphino)ethane)-based complex

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Published: Jun 30, 2023
DOI: https://doi.org/10.5155/eurjchem.14.2.193-201.2402
Keywords:
Viscosity, DNA interaction, Crystal structure, Ru/dppe complex, UV-Vis spectroscopy, Square-wave voltammetry
Section
Research Article
Issue
Vol. 14 No. 2 (2023): June 2023
Dates
Received 2022-12-24
Accepted 2023-02-11
Published 2023-06-30
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Victor Cardoso Campideli
Departamento de Química, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil
http://orcid.org/0000-0001-6262-2268
Jerica Margely Montilla-Suárez
Departamento de Química, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil
http://orcid.org/0000-0001-6898-6652
Tiago Almeida Silva
Departamento de Química, Universidade Federal de Viçosa (UFV), Viçosa, MG, 36570-900, Brazil
http://orcid.org/0000-0002-7202-789X
Dalila Chaves Sicupira
Departamento de Química, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil
http://orcid.org/0000-0003-2552-6845
Katia Mara Oliveira
Instituto de Química, Universidade de Brasília (UnB), Brasília, DF, 70910-900, Brazil
http://orcid.org/0000-0003-4749-0281
Rodrigo Souza Correa
Departamento de Química, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil
http://orcid.org/0000-0003-2783-0816

Abstract

The mixture of cis and trans-[RuCl2(dppe)2] (dppe: 1,2-bis-(diphenylphosphino)ethane) was prepared and the interaction with CT-DNA was evaluated by several methods, including UV-vis DNA spectroscopic titration, viscosity, and electrochemical studies. Investigation suggests that [RuCl2(dppe)2] interacts moderately with CT-DNA. Interestingly, the cis- and trans-isomers interact differently with DNA, as proved by the square-wave voltammetry studies. Finally, the crystal structure of trans-[RuCl2(dppe)2]Cl was obtained from an electrochemical solution and studied in detail, which presents a distorted octahedral geometry and interatomic parameters different from those found in the trans-[RuCl2(dppe)2] complex. Crystal data for C52H48Cl4P4Ru: triclinic, space group P-1 (no. 2), a = 9.240(3) Å, b = 10.9290(18) Å, c = 11.993(3) Å, α = 78.707(11)°, β = 86.712(13)°, γ = 82.598(13)°, V = 1177.1(5) Å3, Z = 1, T = 293(2) K, μ(MoKα) = 0.732 mm-1, Dcalc = 1.467 g/cm3, 8434 reflections measured (6.934° ≤ 2Θ ≤ 51.986°), 4607 unique (Rint = 0.0973, Rsigma = 0.1171) which were used in all calculations. The final R1 was 0.0537 (I > 2σ(I)) and wR2 was 0.1347 (all data).


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Campideli, V. C.; Montilla-Suárez, J. M.; Silva, T. A.; Sicupira, D. C.; Oliveira, K. M.; Correa, R. S. Exploring DNA-Interaction and Molecular Structure of Ruthenium 1,2-Bis-(diphenylphosphino)ethane)-Based Complex. Eur. J. Chem. 2023, 14, 193-201.

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Supporting Agencies

Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG APQ-01674-18) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 311302/2020-3).
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