Design, synthesis, spectral analysis, and biological evaluation of Schiff bases with a 1,3,4-thiadiazole moiety as an effective inhibitor against bacterial and fungal strains

Sajid Ajit Malak; Jamatsing Dabarsing Rajput; Mustakim Sharif

doi:10.5155/eurjchem.14.4.466-472.2468

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Published: Dec 31, 2023

DOI: https://doi.org/10.5155/eurjchem.14.4.466-472.2468

Keywords:

Catalysis, Schiff bases, Thiadiazole, Acetophenone, Antifungal activity, Antibacterial activity

Section

Research Article

Issue

Vol. 14 No. 4 (2023): December 2023

Dates

Received 2023-07-30
Accepted 2023-09-17
Published 2023-12-31

Sajid Ajit Malak

Department of Chemistry, Halimabi Jamaloddin Thim College of Arts and Science, Jalgaon, Maharashtra, 425001, India

https://orcid.org/0009-0005-6738-0399

Jamatsing Dabarsing Rajput

Department of Chemistry, Faculty of Bhagirathi Purnapatre Arts, Sitabai Mangilal Agrawal Science and Kasturbai Khandu Chaudhari Commerce College Chalisgaon, Maharashtra, 424101, India

https://orcid.org/0000-0002-4588-1345

Mustakim Sharif

Department of Chemistry, Halimabi Jamaloddin Thim College of Arts and Science, Jalgaon, Maharashtra, 425001, India

https://orcid.org/0009-0005-1549-4271

Abstract

Many distinct natural and pharmaceutical items include the well-known heterocyclic nucleus 1,3,4-thiadiazole. Ten Schiff bases of 1,3,4-thiadiazole derivatives have been synthesized using equimolar amounts of 5-styryl-1,3,4-thiadiazol-2-amine and substituted acetophenones in the catalytic amount of ethanol. The synthesized derivatives of Schiff's bases were characterized by FT-IR, ¹H NMR, ¹³C NMR, and mass spectroscopy. The 1,3,4-thiadiazole Schiff’s bases (RM-1 to RM-10) were tested for their in vitro antimicrobial activity against Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus using the disc diffusion method. The 1,3,4-thiadiazole Schiff bases showed strong antibacterial activity against bacterial and fungal species, however, their activity was noticeably less effective than that of the evaluated conventional antibiotics.

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Malak, S. A.; Rajput, J. D.; Sharif, M. Design, Synthesis, Spectral Analysis, and Biological Evaluation of Schiff Bases With a 1,3,4-Thiadiazole Moiety As an Effective Inhibitor Against Bacterial and Fungal Strains. Eur. J. Chem. 2023, 14, 466-472.

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Department of Chemistry, Faculty of Bhagirathi Purnapatre Arts, Sitabai Mangilal Agrawal Science and Kasturbai Khandu Chaudhari Commerce College Chalisgaon, Maharashtra, 424101, India.

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