Synthesis, characterization, and biological activities of substituted pyridine-based azomethine scaffolds

Gautam Prabhakar Sadawarte; Jamatsing Darbarsing Rajput; Amol Diliprao Kale; Rajendra Pralhadrao Phase; Vasant Bhagwan Jagrut

doi:10.5155/eurjchem.15.3.226-231.2532

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Published: Sep 30, 2024

DOI: https://doi.org/10.5155/eurjchem.15.3.226-231.2532

Keywords:

Pyridine, Synthesis, Azomethine, Antioxidant, Antimicrobial, Alpha-Amylase

Section

Research Article

Issue

Vol. 15 No. 3 (2024): September 2024

Dates

Received 2024-02-25
Accepted 2024-06-22
Published 2024-09-30

Gautam Prabhakar Sadawarte

Department of Chemistry, Faculty of Science, Bhagirathi Purnapatre Arts, Sitabai Mangilal Agrawal Science and Kasturbai Khandu Chaudhari Commerce College, Chalisgaon, Dist-Jalgaon 424101, Maharashtra State, India

https://orcid.org/0000-0003-2002-0052

Jamatsing Darbarsing Rajput

https://orcid.org/0000-0002-4588-1345

Amol Diliprao Kale

Department of Chemistry, Faculty of Science, Lal Bahadur Shastri Senior College, Partur, Dist-Jalna 431501, Maharashtra State, India

https://orcid.org/0009-0004-5535-1964

Rajendra Pralhadrao Phase

Department of Chemistry, Faculty of Science, Lal Bahadur Shastri Senior College, Partur, Dist-Jalna 431501, Maharashtra State, India

https://orcid.org/0009-0000-4829-7649

Vasant Bhagwan Jagrut

Department of Chemistry, Faculty of Science, Swami Vivekanand Senior College, Mantha, Dist-Jalna 431504, Maharashtra State, India

https://orcid.org/0000-0002-3328-1991

Abstract

The present research work describes the synthesis of a new series of heterocyclic compounds, namely, pyridine-based azomethine scaffolds. A total of eight derivatives were prepared, purified, and characterized by analytical methods such as ¹H NMR, ¹³C NMR, and IR spectroscopic techniques. All compounds were used to investigate their alpha-amylase inhibition activity. We have also reported antimicrobial activity using a micro broth dilution assay, with microbial strains Pseudomonas aeruginosa (NCIM 5031), Escherichia coli (NCIM 2065), Bacillus subtilis (NCIM 2699), Aspergillus niger (NCIM 620), Aspergillus fumigatus (NCIM 902), and Aspergillus flavus (NCIM 549). Finally, we report the antioxidant activity of the synthesized derivatives using a DPPH free radical assay.

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Sadawarte, G. P.; Rajput, J. D.; Kale, A. D.; Phase, R. P.; Jagrut, V. B. Synthesis, Characterization, and Biological Activities of Substituted Pyridine-Based Azomethine Scaffolds. Eur. J. Chem. 2024, 15, 226-231.

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