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A simple, solvent and catalyst-free green synthetic protocol for α-amino phosphonates
Ramesh Katla (1)
, Narayana Murthy Sabbavarapu (2) , Karnakar Konkala (3) , Nageswar Yadavalli Venkata Durga (4,*) (1) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India
(2) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India
(3) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India
(4) Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India
(*) Corresponding Author
Received: 30 Apr 2011 | Revised: 25 May 2011 | Accepted: 25 May 2011 | Published: 31 Mar 2012 | Issue Date: March 2012
Abstract
A simple and efficient method for the synthesis of α-amino phosphonates has been developed by using aromatic aldehydes, amines, and trimethyl/triethyl phosphite, under catalyst and solvent free conditions, with the formation of the product in good to excellent yields. This method involves milder reaction conditions, easy work-up, and cleaner reaction profiles, and may have wide spread application in organic synthesis.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.3.1.119-124.449
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Council of Scientific and Industrial Research, New Delhi
Citations
[1]. Hashem Sharghi, Sakineh Ebrahimpourmoghaddam, Mohammad Mahdi Doroodmand
Iron-doped single walled carbon nanotubes as an efficient and reusable heterogeneous catalyst for the synthesis of organophosphorus compounds under solvent-free conditions
Tetrahedron 69(23), 4708, 2013
DOI: 10.1016/j.tet.2013.03.073
[2]. Hongjun Wang, Tao Deng, Chun Cai
Fluorous bis(oxazolines) ligand: Synthesis and application in Kabachnik-Fields reaction
Journal of Fluorine Chemistry 168, 144, 2014
DOI: 10.1016/j.jfluchem.2014.09.024
[3]. Mario Ordóñez, José Luis Viveros-Ceballos, Carlos Cativiela, Francisco J. Sayago
An update on the stereoselective synthesis of α-aminophosphonic acids and derivatives
Tetrahedron 71(12), 1745, 2015
DOI: 10.1016/j.tet.2015.01.029
[4]. Mohd Nazish, S. Saravanan, Noor-ul H. Khan, Prathibha Kumari, Rukhsana I. Kureshy, Sayed H. R. Abdi, Hari C. Bajaj
Magnetic Fe3O4Nanoparticle-Supported Phosphotungstic Acid as a Recyclable Catalyst for the Kabachnik-Fields Reaction of Isatins, Imines, and Aldehydes under Solvent-Free Conditions
ChemPlusChem , n/a, 2014
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European Journal of Chemistry 5(4), 668, 2014
DOI: 10.5155/eurjchem.5.4.668-670.1085
[6]. Jilla Shankar, Gaddam Satish, Katla Ramesh, Nageswar Yadavalli Venkata Durga
Aqueous phase synthesis of polysubstituted pyrimidines/pyrrolidines catalyzed by β-cyclodextrin
European Journal of Chemistry 5(3), 541, 2014
DOI: 10.5155/eurjchem.5.3.541-544.1049
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