European Journal of Chemistry

A simple, solvent and catalyst-free green synthetic protocol for α-amino phosphonates

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Published: Mar 31, 2012
DOI: https://doi.org/10.5155/eurjchem.3.1.119-124.449
Keywords:
Amines, Solvent-free, Neat condition, Aromatic aldehydes, Multi component reaction, Trimethyl/triethyl phosphite
Section
Short Communication
Issue
Vol. 3 No. 1 (2012): March 2012
Dates
Received 2011-04-30
Accepted 2011-05-25
Published 2012-03-31


Main Article Content

Ramesh Katla
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India
Narayana Murthy Sabbavarapu
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India
Karnakar Konkala
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India
Nageswar Yadavalli Venkata Durga
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500607, India

Abstract

A simple and efficient method for the synthesis of α-amino phosphonates has been developed by using aromatic aldehydes, amines, and trimethyl/triethyl phosphite, under catalyst and solvent free conditions, with the formation of the product in good to excellent yields. This method involves milder reaction conditions, easy work-up, and cleaner reaction profiles, and may have wide spread application in organic synthesis.

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(1)
Katla, R.; Sabbavarapu, N. M.; Konkala, K.; Durga, N. Y. V. A Simple, Solvent and Catalyst-Free Green Synthetic Protocol for α-Amino Phosphonates. Eur. J. Chem. 2012, 3, 119-124.

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