European Journal of Chemistry

Aqueous phase synthesis of polysubstituted pyrimidines/pyrrolidines catalyzed by β-cyclodextrin



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Jilla Shankar
Gaddam Satish
Katla Ramesh
Nageswar Yadavalli Venkata Durga

Abstract

Highly substituted pyrimidine/pyrrolidine derivatives were synthesized for the first time in water under neutral conditions by the reaction of aromatic amines, dimethyl/diethyl acetylene dicarboxylates, formaldehyde mediated by β-cyclodextrin (β-CD) in good to excellent yields. β-Cyclodextrin can be recovered and reused without any loss of catalytic activity. The β-Cyclodextrins employed were inexpensive and readily available when compared to other types of cyclodextrins (α, γ).


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Shankar, J.; Satish, G.; Ramesh, K.; Durga, N. Y. V. Aqueous Phase Synthesis of Polysubstituted Pyrimidines Pyrrolidines Catalyzed by β-Cyclodextrin. Eur. J. Chem. 2014, 5, 541-544.

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Council of Scientific and Industrial Research, New Delhi, India
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