European Journal of Chemistry

Aqueous phase synthesis of polysubstituted pyrimidines/pyrrolidines catalyzed by β-cyclodextrin

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Published: Sep 30, 2014
DOI: https://doi.org/10.5155/eurjchem.5.3.541-544.1049
Keywords:
Amines, Formaldehyde, β-Cyclodextrin, Pyrimidine derivatives, Pyrrolidine derivatives, Dimethyl/diethyl acetylene dicarboxylates
Section
Short Communication
Issue
Vol. 5 No. 3 (2014): September 2014
Dates
Received 2014-03-13
Accepted 2014-04-22
Published 2014-09-30


Main Article Content

Jilla Shankar
Council of Scientific and Industrial Research-Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500-007, India
Gaddam Satish
Council of Scientific and Industrial Research-Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500-007, India
Katla Ramesh
Council of Scientific and Industrial Research-Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500-007, India
Nageswar Yadavalli Venkata Durga
Council of Scientific and Industrial Research-Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500-007, India

Abstract

Highly substituted pyrimidine/pyrrolidine derivatives were synthesized for the first time in water under neutral conditions by the reaction of aromatic amines, dimethyl/diethyl acetylene dicarboxylates, formaldehyde mediated by β-cyclodextrin (β-CD) in good to excellent yields. β-Cyclodextrin can be recovered and reused without any loss of catalytic activity. The β-Cyclodextrins employed were inexpensive and readily available when compared to other types of cyclodextrins (α, γ).


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How to Cite
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Shankar, J.; Satish, G.; Ramesh, K.; Durga, N. Y. V. Aqueous Phase Synthesis of Polysubstituted Pyrimidines Pyrrolidines Catalyzed by β-Cyclodextrin. Eur. J. Chem. 2014, 5, 541-544.

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Council of Scientific and Industrial Research, New Delhi, India
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