European Journal of Chemistry

Synthesis and reactions of 3-aminotetrachloroquinazolin-2,4-dione

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Published: Dec 31, 2011
DOI: https://doi.org/10.5155/eurjchem.2.4.514-518.479
Keywords:
Quinazolinedione, Hydrazine hydrate, Anti-inflammatory, Tetrachloroquinazolindione, N-Phenylsulphonyloxytetrachlorophthalimide, 3-(N-acetylamino)tetrachloroquinazolindione
Section
Research Article
Issue
Vol. 2 No. 4 (2011): December 2011
Dates
Received 2011-06-21
Accepted 2011-07-31
Published 2011-12-31


Main Article Content

Mamdouh Adly Hassan
Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt
Ahmed Mohamed Mosalem Younes
Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt
Mohamed Mobark Taha
Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt
Abou-Bakr Haredy Abdel-Monsef
Chemistry Department, Faculty of Science, South Valley University, Qena-83523, Egypt

Abstract

N-phenylsulphonyloxytetrachlorophthalimide was obtained by treatment of N-hydroxy tetrachlorophthalimide with benzenesulphonyl chloride. Also, the titled compound 3 was obtained by reaction of compound 2 with hydrazine hydrate via Lossen rearrangement. Compound 3 used as starting material for the synthesis of new pyrimidine and quinazolinedione derivatives containing four chlorine atoms which have pharmacological activity.

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How to Cite
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Hassan, M. A.; Younes, A. M. M.; Taha, M. M.; Abdel-Monsef, A.-B. H. Synthesis and Reactions of 3-Aminotetrachloroquinazolin-2,4-Dione. Eur. J. Chem. 2011, 2, 514-518.

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