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Green synthesis of novel pyrazole containing Schiff base derivatives as antibacterial agents on the bases of in-vitro and DFT
Salman Ahmad Khan (1,*)
, Abdullah Mohamed Asiri (2) , Abdulrhim Alabbas Basheike (3) , Kamlesh Sharma (4) (1) Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
(2) Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
(3) Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
(4) Molecular Science Research Institute, School of Chemistry, University of the Witwatersrand, PO Wits 2050, Johannesburg, South Africa
(*) Corresponding Author
Received: 25 Mar 2013 | Revised: 23 Apr 2013 | Accepted: 07 May 2013 | Published: 31 Dec 2013 | Issue Date: December 2013
Abstract
A series of pyrazole containing Schiff bases were synthesized, by the reaction of 3,5-dimethyl-1-phenylpyrazole-4-carboxaldehyde and the corresponding active amines under microwave irradiation. The structures of the synthesized compounds were established by spectroscopic data (FT-IR, 1H NMR, 13C NMR and ESI-MS) and elemental analyses. The anti-bacterial activity of these compounds were tested in vitro by the disc diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration using chloramphenicol as reference drug. All the molecules were modeled and optimized by using density functional theory, DFT/B3LYP method. Calculated descriptors, the lower unoccupied molecular orbital and the density were used to interpret the antibacterial activity of the compounds. The results showed that compound 3 is better inhibitor of both types of test bacteria as compared to chloramphenicol.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.4.4.454-458.784
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Funding information
Department of Chemistry and Center of Excellence for Advance Materials at King Abdulaziz University
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[4]. Marie-Hélène Tremblay, Thomas Skalski, Yohan Gautier, Grégory Pianezzola, W. G. Skene
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DOI Link: https://doi.org/10.5155/eurjchem.4.4.454-458.784
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European Journal of Chemistry 2013, 4(4), 454-458 | doi: https://doi.org/10.5155/eurjchem.4.4.454-458.784 | Get rights and content
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