Synthesis of some new fluorine substituted thiobarbituric acid derivatives as anti HIV1 and cyclin-dependent kinase 2 (CDK2) for cell tumor division: Part I

Abdulrahman Salim Al-Harbi; Reda Mohammady Abdel-Rahman; Abdullah Mohamed Asiri

doi:10.5155/eurjchem.6.1.63-70.1147

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Published: Mar 31, 2015

DOI: https://doi.org/10.5155/eurjchem.6.1.63-70.1147

Keywords:

CDK2, Anti HIV, Synthesis, Heterocyclic, Potential inhibitors, Fluorinated thiobarbituric

Section

Research Article

Issue

Vol. 6 No. 1 (2015): March 2015

Dates

Received 2014-09-11
Accepted 2014-10-18
Published 2015-03-31

Abdulrahman Salim Al-Harbi

Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, 21589, Kingdom of Saudi Arabia

Reda Mohammady Abdel-Rahman

Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, 21589, Kingdom of Saudi Arabia

Abdullah Mohamed Asiri

Centre of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia

Abstract

New potential enzyme inhibitors, fluorine-substituted thiobarbituric acid derivatives (2, 3, 9, 8 and 12) and their fused/isolated heterocyclic nitrogen systems (5, 6, 10 and 14) have been obtained from heterocyclization of fluorinated N, Nʹ-disubstituted thiourea (1, 7 and 11) with malonic acid followed by ring closure reactions with primary nitrogen reagents. Structures of the synthesized products have been deduced from their elemental analysis and spectral data. Anti-HIV-1 and inhibition of cyclin-dependent kinase2 (CDK2) for cell tumor division for the synthesized compounds were also evaluated.

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Al-Harbi, A. S.; Abdel-Rahman, R. M.; Asiri, A. M. Synthesis of Some New Fluorine Substituted Thiobarbituric Acid Derivatives As Anti HIV1 and Cyclin-Dependent Kinase 2 (CDK2) for Cell Tumor Division: Part I. Eur. J. Chem. 2015, 6, 63-70.

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