1,1-Diphenyl-2-picrylhydrazyl radical scavenging activity of novel dihydropyridine derivatives

Ayaz Anwar; Abdul Hameed; Shahida Perveen; Maliha Uroos; Muhammad Iqbal Choudhary; Fatima Zahra Basha

doi:10.5155/eurjchem.5.1.189-191.916

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Published: Mar 31, 2014

DOI: https://doi.org/10.5155/eurjchem.5.1.189-191.916

Keywords:

Oxidative stress, Antioxidant activity, Reactive oxygen species, DPPH radical scavengers, Knoevenagel condensation, Dihydropyridine derivatives

Section

Short Communication

Issue

Vol. 5 No. 1 (2014): March 2014

Dates

Received 2013-09-04
Accepted 2013-10-26
Published 2014-03-31

Ayaz Anwar

Husein Ebrahim Jamal Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Abdul Hameed

Husein Ebrahim Jamal Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Shahida Perveen

Husein Ebrahim Jamal Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Maliha Uroos

Institute of Agricultural Sciences, University of the Punjab, Quaid-e-Azam Campus, Lahore, 54590 Pakistan

Muhammad Iqbal Choudhary

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah-21412, Saudi Arabia

Fatima Zahra Basha

Husein Ebrahim Jamal Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Abstract

Thirteen dihydropyridine analogues 1-13 were synthesized and evaluated for their DPPH radical scavenging activity. A good to moderate antioxidant activity ranging from 127.4 to 284.5 μM was observed and structure-activity relationship was established. The 3'-fluoro derivative 8 (IC₅₀ = 127.4±3.5 μM) was found to exhibit highest activity among the dihydro pyridine derivatives 1-13, while the other derivatives 11 (IC₅₀ = 132.5±3.32 μM), 6 (IC₅₀ = 142.2±0.60 μM), 10 (IC₅₀ = 144.7±2.46 μM), 12 (IC₅₀ = 153.7±0.50 μM), 5 (IC₅₀ = 161.4±2.81 μM) and 5 (IC₅₀ = 164.4±2.50 μM) possess moderate activity, depends upon the C-4 and C-6 substituted groups. The compounds 7, 13, 4, 3 and 2 have lowest IC₅₀ values, ranging between 172.8 and 284.5 μM. Dihydropyridine analogues were characterized by spectroscopic techniques.

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Anwar, A.; Hameed, A.; Perveen, S.; Uroos, M.; Choudhary, M. I.; Basha, F. Z. 1,1-Diphenyl-2-Picrylhydrazyl Radical Scavenging Activity of Novel Dihydropyridine Derivatives. Eur. J. Chem. 2014, 5, 189-191.

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Supporting Agencies

Higher Education Commission (HEC), Pakistan and Husein Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

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