European Journal of Chemistry 2015, 6(1), 63-70 | doi: https://doi.org/10.5155/eurjchem.6.1.63-70.1147 | Get rights and content






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Synthesis of some new fluorine substituted thiobarbituric acid derivatives as anti HIV1 and cyclin-dependent kinase 2 (CDK2) for cell tumor division: Part I


Abdulrahman Salim Al-Harbi (1,*) , Reda Mohammady Abdel-Rahman (2) , Abdullah Mohamed Asiri (3)

(1) Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, 21589, Kingdom of Saudi Arabia
(2) Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, 21589, Kingdom of Saudi Arabia
(3) Centre of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia
(*) Corresponding Author

Received: 11 Sep 2014 | Revised: 13 Oct 2014 | Accepted: 18 Oct 2014 | Published: 31 Mar 2015 | Issue Date: March 2015

Abstract


New potential enzyme inhibitors, fluorine-substituted thiobarbituric acid derivatives (2, 3, 9, 8 and 12) and their fused/isolated heterocyclic nitrogen systems (5, 6, 10 and 14) have been obtained from heterocyclization of fluorinated N, Nʹ-disubstituted thiourea (1, 7 and 11) with malonic acid followed by ring closure reactions with primary nitrogen reagents. Structures of the synthesized products have been deduced from their elemental analysis and spectral data. Anti-HIV-1 and inhibition of cyclin-dependent kinase2 (CDK2) for cell tumor division for the synthesized compounds were also evaluated.


Keywords


CDK2; Anti HIV; Synthesis; Heterocyclic; Potential inhibitors; Fluorinated thiobarbituric

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DOI: 10.5155/eurjchem.6.1.63-70.1147

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How to cite


Al-Harbi, A.; Abdel-Rahman, R.; Asiri, A. Eur. J. Chem. 2015, 6(1), 63-70. doi:10.5155/eurjchem.6.1.63-70.1147
Al-Harbi, A.; Abdel-Rahman, R.; Asiri, A. Synthesis of some new fluorine substituted thiobarbituric acid derivatives as anti HIV1 and cyclin-dependent kinase 2 (CDK2) for cell tumor division: Part I. Eur. J. Chem. 2015, 6(1), 63-70. doi:10.5155/eurjchem.6.1.63-70.1147
Al-Harbi, A., Abdel-Rahman, R., & Asiri, A. (2015). Synthesis of some new fluorine substituted thiobarbituric acid derivatives as anti HIV1 and cyclin-dependent kinase 2 (CDK2) for cell tumor division: Part I. European Journal of Chemistry, 6(1), 63-70. doi:10.5155/eurjchem.6.1.63-70.1147
Al-Harbi, Abdulrahman, Reda Mohammady Abdel-Rahman, & Abdullah Mohamed Asiri. "Synthesis of some new fluorine substituted thiobarbituric acid derivatives as anti HIV1 and cyclin-dependent kinase 2 (CDK2) for cell tumor division: Part I." European Journal of Chemistry [Online], 6.1 (2015): 63-70. Web. 4 Jul. 2020
Al-Harbi, Abdulrahman, Abdel-Rahman, Reda, AND Asiri, Abdullah. "Synthesis of some new fluorine substituted thiobarbituric acid derivatives as anti HIV1 and cyclin-dependent kinase 2 (CDK2) for cell tumor division: Part I" European Journal of Chemistry [Online], Volume 6 Number 1 (31 March 2015)

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