1,2,4-Triazine Chemistry Part I: Orientation of cyclization reactions of functionalized 1,2,4-triazine derivatives

Reda Mohammady Abdel-Rahman; Mohammed Saleh Tawfik Makki; Tarik El-Sayed Ali; Magdy Ahmed Ibrahim

doi:10.5155/eurjchem.1.3.236-245.54

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Published: Sep 29, 2010

DOI: https://doi.org/10.5155/eurjchem.1.3.236-245.54

Keywords:

1, 2, 4-Triazines, Chemical reactivity, Cyclization reactions

Section

Review Article

Issue

Vol. 1 No. 3 (2010): September 2010

Dates

Received 2010-04-10
Accepted 2010-06-29
Published 2010-09-29

Reda Mohammady Abdel-Rahman

Department of Chemistry, Faculty of Science, King Abdel-Aziz University, Jeddah, 21589, Saudi Arabia

Mohammed Saleh Tawfik Makki

Department of Chemistry, Faculty of Science, King Abdel-Aziz University, Jeddah, 21589, Saudi Arabia

Tarik El-Sayed Ali

Department of Chemistry, Faculty of Education, Ain shams University, Roxy, 11711, Cairo, Egypt

Magdy Ahmed Ibrahim

Department of Chemistry, Faculty of Education, Ain shams University, Roxy, 11711, Cairo, Egypt

Abstract

Orientation of heterocyclization reactions of functionalized 1,2,4-triazines were studied by effect of substituents in 1,2,4-triazine moieties, type of the solvent used in the reaction and the temperature effect. Also, it was found that cyclization process depended mainly on the chemoselective and regioselectivity states of the parent substrate as well as preferring cite of ring closure.

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Abdel-Rahman, R. M.; Makki, M. S. T.; Ali, T. E.-S.; Ibrahim, M. A. 1,2,4-Triazine Chemistry Part I: Orientation of Cyclization Reactions of Functionalized 1,2,4-Triazine Derivatives. Eur. J. Chem. 2010, 1, 236-245.

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