European Journal of Chemistry

Synthesis of novel pyrimidine and fused pyrimidine derivatives

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Published: Sep 30, 2011
DOI: https://doi.org/10.5155/eurjchem.2.3.347-355.168
Keywords:
s-Benzylthiuronium chloride, Activated nitriles, Pyrimidines, Triazolopyrimidine derivatives, Antiviral activity, Cytotoxicity
Section
Research Article
Issue
Vol. 2 No. 3 (2011): September 2011
Dates
Received 2010-06-15
Accepted 2010-11-08
Published 2011-09-30


Main Article Content

Mahmoud Refaee Mahmoud
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt
Ahmed Kamel El-Ziaty
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt
Mahmoud Fawzy Ismail
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt
Sayed Ahmed Shiba
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt

Abstract

4-Amino-2-(benzylthio)-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile (1) was prepared by treatment of s-benzylthiuronium chloride with 2-(4-methoxybenzylidene)malononitrile in ethanolic sodium hydroxide with hydrazine hydrate to afford the hydrazino derivative 2, which was allowed to react with different electrophilic reagents to give the pyrimidine derivatives 3-12. The proclivity of (E)-2-cyano-3-(4-nitrophenyl)acrylamide (13) towards carbon and nitrogen nucleophiles was also investigated. IR, 1H NMR and mass spectra for all the synthesized compounds were discussed. All derived compounds were investigated for anti avian influenza (H5N1) virus activity and compared with zanamivir as control drug. All the synthesized compounds didn’t possess any antiviral activity.

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Mahmoud, M. R.; El-Ziaty, A. K.; Ismail, M. F.; Shiba, S. A. Synthesis of Novel Pyrimidine and Fused Pyrimidine Derivatives. Eur. J. Chem. 2011, 2, 347-355.

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Author Biography

Mahmoud Fawzy Ismail, Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt


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