European Journal of Chemistry

Synthesis of novel quinazolinone and fused quinazolinones

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Mahmoud Refaee Mahmoud
Manal Mohamed El-Shahawi
Fatma Saber Mohamed Abu El-Azm


A number of novel quinazolinone derivatives have been synthesized using the readily obtainable 2-[(1Z,3E)-1-benzamido-4-phenyl-1,3-butadien-1-yl]-3,1-benzoxazin-4(H)one (1) via the reaction with different nitrogen nucleophiles such as azines, Schiff’s base, primary aromatic amines, diamines, hydrazine hydrate and hydroxylamine.


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Mahmoud, M. R.; El-Shahawi, M. M.; Abu El-Azm, F. S. M. Synthesis of Novel Quinazolinone and Fused Quinazolinones. Eur. J. Chem. 2011, 2, 404-409.

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