European Journal of Chemistry

Novel isoquinoline derivatives from isochromen-1,3-dione

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Published: Jun 15, 2010
DOI: https://doi.org/10.5155/eurjchem.1.2.134-139.71
Keywords:
Isochromene-1, 3-dione, Isoquinolines, 2-Cyanoethanoic hydrazide, Nitrogen nucleophiles
Section
Research Article
Issue
Vol. 1 No. 2 (2010): June 2010
Dates
Received 2010-04-21
Accepted 2010-05-12
Published 2010-06-15


Main Article Content

Mahmoud Refaee Mahmoud
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
Manal Mohamed El-Shahawi
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
Eman Abd El-Fattah El-Bordany
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
Fatma Saber Mohamed Abu El-Azm
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt

Abstract

A number of novel isoquinoline derivatives have been synthesized using the readily obtainable (E)-4-(3,4-dimethoxybenzylidene)-4H-isochromene-1,3-dione, 2, via the reaction with different nitrogen nucleophiles such as cyanoethanoic hydrazide, cyclohexylamine, 2-aminothiophenol and p-toluenesulfonohydrazide. Furthermore, the reactivity of 2 towards thiophenol, and ethylcyanoacetate has been investigated.

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Mahmoud, M. R.; El-Shahawi, M. M.; El-Bordany, E. A. E.-F.; Abu El-Azm, F. S. M. Novel Isoquinoline Derivatives from Isochromen-1,3-Dione. Eur. J. Chem. 2010, 1, 134-139.

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