

A mild and efficient method for the deprotection of trimethyl silyl alkynes using sodium ascorbate and copper sulphate
Ranjith Siddaraj (1)




(1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India
(3) Department of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS Technical Institutions Campus, Mysore 570006, Karnataka, India
(4) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India
(*) Corresponding Author
Received: 03 May 2018 | Revised: 02 Jul 2018 | Accepted: 08 Jul 2018 | Published: 31 Dec 2018 | Issue Date: December 2018
Abstract
A competent and fast method for the deprotection of trimethyl silyl group was attained by using cheap, easily accessible, and nontoxic sodium ascorbate in combination with copper sulphate. The method labored was simple and effective for the cleavage of trimethyl silyl group from the protected trimethyl silyl alkynes to their corresponding alkyne derivatives. Wide functional group tolerance, shorter time period, simple procedure and high yields are the striking features of this protocol.
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DOI: 10.5155/eurjchem.9.4.317-321.1729
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