A novel and expeditious synthesis of oxazolidinone drugs linezolid and eperezolid

Ranjith Siddaraj; Shivaraja Govindaiah; Raghu Ningegowda; Nanjunda Swamy Shivananju; Babu Shubha Priya

doi:10.5155/eurjchem.9.4.353-359.1783

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Published: Dec 31, 2018

DOI: https://doi.org/10.5155/eurjchem.9.4.353-359.1783

Keywords:

Linezolid, Eperezolid, Acetamide, Sodium iodide, Cesium carbonate, (R)-2-(Bromomethyl)oxirane

Section

Research Article

Issue

Vol. 9 No. 4 (2018): December 2018

Dates

Received 2018-08-28
Accepted 2018-10-06
Published 2018-12-31

Ranjith Siddaraj

Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570006, Karnataka, India

http://orcid.org/0000-0002-4780-9144

Shivaraja Govindaiah

Department of Studies and Research in Chemistry, Tumkur University, Tumkur-572103, Karnataka, India

http://orcid.org/0000-0001-7545-4611

Raghu Ningegowda

Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570006, Karnataka, India

http://orcid.org/0000-0003-4817-4061

Nanjunda Swamy Shivananju

Department of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS Technical Institutions Campus, Mysore-570006, Karnataka, India

http://orcid.org/0000-0002-5494-9428

Babu Shubha Priya

Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570006, Karnataka, India

http://orcid.org/0000-0003-1110-0771

Abstract

A concise and efficient synthesis of linezolid and eperezolid were accomplished through a convergent scheme utilizing diverse reaction conditions. The synthesis demonstrates utility of a new approach to facilitate the expeditious construction of 3-aryl-5-(substituted methyl)-2-oxazolidinones and easier insertion of N-acetyl group. This new approach offers the possibility of accessing related 2-oxazolidinone members easily as well as making additional analogues of Linezolid. The adopted method afforded high purity and excellent yield compared to other existing synthetic methods. The compounds were successfully characterized by known spectroscopic techniques.

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How to Cite

(1)

Siddaraj, R.; Govindaiah, S.; Ningegowda, R.; Shivananju, N. S.; Priya, B. S. A Novel and Expeditious Synthesis of Oxazolidinone Drugs Linezolid and Eperezolid. Eur. J. Chem. 2018, 9, 353-359.

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