European Journal of Chemistry

Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one

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Assia Sid
Nouara Ziani
Ouafa Demmen-Debbih
Mahieddine Mokhtari
Kaddour Lamara


1-((5,3-Diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one, 6-10, have been synthesized by the reaction of chalcone derivatives, 1-5, with hydrazine hydrate in hot propanoic acid solution. All these compounds were characterized by different spectroscopic techniques (FT-IR, 1H and 13C NMR) and elemental analyses. All the synthesized products were evaluated for antimicrobial activity. All the compounds exhibited significant to moderate antimicrobial activity.


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Sid, A.; Ziani, N.; Demmen-Debbih, O.; Mokhtari, M.; Lamara, K. Synthesis, Characterization and Antimicrobial Evaluation of 1-(5,3-Diaryl)-4,5-Dihydro-1H-Pyrazol-1-yl)propan-1-One. Eur. J. Chem. 2013, 4, 268-271.

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Laboratory of Applied Chemistry and Materials Technology of the University of Oum El Bouaghi, Rue de Constantine, Algeria
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