European Journal of Chemistry

A microwave-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione derivatives using nanocrystalline MgFe2O4 as catalyst

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Published: Mar 31, 2014
DOI: https://doi.org/10.5155/eurjchem.5.1.122-126.911
Keywords:
Catalyst, Biginelli reaction, Microwave technique, Nanocrystalline MgFe2O4, 3, 4-Dihydropyrimidinones, 4-Dihydropyrimidine thiones
Section
Research Article
Issue
Vol. 5 No. 1 (2014): March 2014
Dates
Received 2013-08-27
Accepted 2013-09-27
Published 2014-03-31


Main Article Content

Chandrashekhar Arunrao Ladole
Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India
Nilesh Govindrao Salunkhe
Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India
Ravindra Sakharam Bhaskar
Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India
Anand Shankarrao Aswar
Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India

Abstract

3,4-Dihydropyrimidin-2(1H)-one/thione derivatives were synthesized in moderate to high yields via one-pot three component Biginelli reaction of aldehydes, ethyl acetoacetate and urea/thiourea in the presence of nanocrystalline MgFe2O4 as an efficient catalyst, in microwave irradiation under solvent free condition. This protocol offers several advantages including good yields of products, short reaction time and easy work-up procedure.

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Ladole, C. A.; Salunkhe, N. G.; Bhaskar, R. S.; Aswar, A. S. A Microwave-Assisted Synthesis of 3,4-Dihydropyrimidin-2(1H)-One Thione Derivatives Using Nanocrystalline MgFe2O4 As Catalyst. Eur. J. Chem. 2014, 5, 122-126.

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