European Journal of Chemistry

Synthesis and antimicrobial activity of some new 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties



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Tarik El-Sayed Ali
Azza Mohammed El-Kazak

Abstract

Some new sulfur-nitrogen heterocyclic systems such as 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties were synthesized via heterocyclization of the key intermediate 4-(acridin-9-yl)-1-(1,2,3,4-tetrahydroacridin-9-ylcarbonyl)thiosemicarbazide. Structures of the new comp-ounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity.

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Ali, T. E.-S.; El-Kazak, A. M. Synthesis and Antimicrobial Activity of Some New 1,3-Thiazoles, 1,3,4-Thiadiazoles, 1,2,4-Triazoles and 1,3-Thiazines Incorporating Acridine and 1,2,3,4-Tetrahydroacridine Moieties. Eur. J. Chem. 2010, 1, 6-11.

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