Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit

Salah Abdel-Ghaffar Abdel-Aziz; Tarik El-Sayed Ali; Kamilia Mohamed El-Mahdy; Somaia Mohamed Abdel-Karim

doi:10.5155/eurjchem.2.1.25-35.208

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Published: Mar 28, 2011

DOI: https://doi.org/10.5155/eurjchem.2.1.25-35.208

Keywords:

Phosphonicdihydrazones, Hydro-phosphoryl, Vilsmeier-Haack reaction, Bis-pyrazoles, Sulfur-phosphorus heterocycles, Antimicrobial activity

Section

Research Article

Issue

Vol. 2 No. 1 (2011): March 2011

Dates

Received 2010-07-15
Accepted 2010-08-03
Published 2011-03-28

Salah Abdel-Ghaffar Abdel-Aziz

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt

Tarik El-Sayed Ali

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt

Kamilia Mohamed El-Mahdy

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt

Somaia Mohamed Abdel-Karim

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt

Abstract

Vilsmeier-Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis-pyrazole derivatives containing a hydro-phosphoryl unit. Bis-{4-formyl-3-aryl-1H-pyrazol-1-yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4-phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis-pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities.

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Abdel-Aziz, S. A.-G.; Ali, T. E.-S.; El-Mahdy, K. M.; Abdel-Karim, S. M. Synthesis and Antimicrobial Activities of Some Novel Bis-Pyrazole Derivatives Containing a Hydrophosphoryl Unit. Eur. J. Chem. 2011, 2, 25-35.

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