Synthesis and X-ray crystallography of (1R,3aR,7aR)-1-((S)-1-((2R,5S)-5-(3-hydroxypentan-3-yl)tetrahydrofuran-2-yl)ethyl)-7a-methyloctahydro-4H-inden-4-one

Modou Lo; Andrea Martínez; Hugo Santalla; Fátima Garrido; Aliou Hamady Barry; Mohamed Gaye

doi:10.5155/eurjchem.8.3.248-251.1602

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Published: Sep 30, 2017

DOI: https://doi.org/10.5155/eurjchem.8.3.248-251.1602

Keywords:

Calcitriol, Vitamin D, Crystal structure, NMR spectroscopy, Pyridinium dichromate, Heterocycle compounds

Section

Research Article

Issue

Vol. 8 No. 3 (2017): September 2017

Dates

Received 2017-06-21
Accepted 2017-07-15
Published 2017-09-30

Modou Lo

Department of Chemistry, University Cheikh Anta Diop, Dakar, 10700, Senegal

Andrea Martínez

Dipartamento Química Orgínica, Facultade de Química, Universidade de Vigo, Vigo, 36310, Spain

Hugo Santalla

Dipartamento Química Orgínica, Facultade de Química, Universidade de Vigo, Vigo, 36310, Spain

Fátima Garrido

Dipartamento Química Orgínica, Facultade de Química, Universidade de Vigo, Vigo, 36310, Spain

Aliou Hamady Barry

Department of Chemistry, University of Nouakchott, Nouakchott, 130301, Mauritania

Mohamed Gaye

Department of Chemistry, University Cheikh Anta Diop, Dakar, 10700, Senegal

Abstract

The crystal of the title compound, C₂₁H₃₆O₃ contains an oxolane ring, and six defined stereocenters which are unambigously established by the crystallography study. A three dimensional supramolecular architecture is ensured by hydrogen bonds from the hydroxy group which is both engaged in inter (O-H···O2) and intramolecular C-H···O-H) hydrogen bonds. Weak C-H···O=C hydrogen bonds are involved also into the consolidation of the network.

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How to Cite

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Lo, M.; Martínez, A.; Santalla, H.; Garrido, F.; Barry, A. H.; Gaye, M. Synthesis and X-Ray Crystallography of (1R,3aR,7aR)-1-(S)-1-(2R,5S)-5-(3-Hydroxypentan-3-yl)tetrahydrofuran-2-yl)ethyl)-7a-Methyloctahydro-4H-Inden-4-One. Eur. J. Chem. 2017, 8, 248-251.

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References

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Supporting Agencies

The University of Vigo (Spain) and the Sonatel Fondation

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