Green methodologies in organic synthesis: Microwave assisted solvent- and catalyst-free synthesis of enaminones and their conversion into 1,3,5-trisubstituted benzenes as well as 3-aroyl-6-substituted pyridines

Morsy Ahmed El-Apasery; Saleh Mohamed Al-Mousawi; Mohamed Helmy Elnagdi

doi:10.5155/eurjchem.2.2.168-172.228

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Published: Jun 30, 2011

DOI: https://doi.org/10.5155/eurjchem.2.2.168-172.228

Keywords:

Enaminone, Solvent-free, Green chemistry, Dye intermediates, Microwave irradiation, 1, 3, 5-trisubstituted benzenes

Section

Research Article

Issue

Vol. 2 No. 2 (2011): June 2011

Dates

Received 2010-08-03
Accepted 2010-11-16
Published 2011-06-30

Morsy Ahmed El-Apasery

Department of Chemistry, Faculty of Science, Kuwait University, Safat, 13060, Kuwait

Saleh Mohamed Al-Mousawi

Department of Chemistry, Faculty of Science, Kuwait University, Safat, 13060, Kuwait

Mohamed Helmy Elnagdi

Department of Chemistry, Faculty of Science, Kuwait University, Safat, 13060, Kuwait

Abstract

Enaminones were obtained in good yields via condensing methyl ketones with (N,N-dimethylformamide dimethyl acetal) DMF-DMA under microwave irradiation in absence of solvent. These enaminones were readily converted into 1,3,5-trisubstituted benzenes. Reacting enaminones in presence of ammonium acetate has afforded pyridine derivatives. 2_2_168_172_800

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El-Apasery, M. A.; Al-Mousawi, S. M.; Elnagdi, M. H. Green Methodologies in Organic Synthesis: Microwave Assisted Solvent- and Catalyst-Free Synthesis of Enaminones and Their Conversion into 1,3,5-Trisubstituted Benzenes As Well As 3-Aroyl-6-Substituted Pyridines. Eur. J. Chem. 2011, 2, 168-172.

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Supporting Agencies

Kuwait University

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