European Journal of Chemistry

Reactions with hydrazonoyl halides 65: Synthesis of some new 1,3,4-thiadiazoles and triazolino[4,3-a]pyrimidines containing pyrazole moiety

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Abdou Osman Abdelhamid
Abdelgawad Ali Fahmi
Karema Noury Mahmoud Halim


2,3-Dihydro-1,3,4-thiadiazoles, and triazolino[4,3-a]pyrimidines containing pyrazole moieties were prepared from the reaction of alkyl 2-[1-(4-cyano-1,5-diphenyl-1H-pyrazol-3-yl)ethylidene]hydrazinecarbodithioate and pyrimidine-2-thione derivatives with appropriate hydrazonoyl halides. The structures of all the newly synthesized compounds were confirmed by elemental analyses, spectral data, and alternative route of synthesis whenever possible.


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Abdelhamid, A. O.; Fahmi, A. A.; Halim, K. N. M. Reactions With Hydrazonoyl Halides 65: Synthesis of Some New 1,3,4-Thiadiazoles and triazolino[4,3-a]pyrimidines Containing Pyrazole Moiety. Eur. J. Chem. 2011, 2, 317-323.

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[1]. Trost, B. M. Chem. Rev. 1978, 78, 363-382.

[2]. Ganellin, R. J. Med. Chem. 1981, 24, 913-920.

[3]. Dogan, H. N.; Rollas, S.; Erdeniz, H. Farmaco. 1998, 53, 462-467.

[4]. Dogan, H. N.; Duran, A.; Rollas, S.; Sener, G.; Uysal, M. K.; Gulen, D. Bioorg. Med. Chem. 2002, 10, 2893-2898.

[5]. Palaska, E.; Sahin, G.; Kelicen, P.; Durlu, N. T.; Altinok, G. Farmaco. 2002, 57, 101-107.

[6]. Karakus, S.; Rollas, S. Farmaco. 2002, 57, 577-581.

[7]. Terzioglu, N.; Gursoy. A. Eur. J. Med. Chem. 2003, 38, 781-786.

[8]. Stetter, H.; Rauscher, E. Chem. Ber. 1960, 93, 2054-2057.

[9]. Ryan, A. J.; Welling, P. G.; Wright, S. E. Food. Cosmet. Toxicol. 1969, 7(4), 287-295.

[10]. Ebnother, A.; Jucker, E.; Lindenmann, A. Helv. Chim. Acta 1959, 42, 1201-1214.

[11]. Burger, A. Medicinal Chemistry, 2nd ed. Interscience, New York, 1945, pp. 345.

[12]. Kueffner, K.; Marx, P.; Laessig, W. Ger. Offen. DE 3, 217, 877 17 Nov 1983, pp. 53. Chem. Abstr., 100, 183105p (1984).

[13]. Abolin, A. G.; Balabanov E. I.; Bespalov, B. P.; Bukin, Y. I.; Rumyantsev, B. M.; Titov, V. V.; Yudina, G. I. Zh. Nauch. Prikl. Fotogr. 1981, 26, 182-193.

[14]. Abdelhamid, A. O.; Abdelall, E. K. A.; Zaki, Y. H. J. Heterocycl. Chem. 2010, 47, 477-482.

[15]. Abdelhamid, A. O.; Afifi, M. A. M. J. Adv. Res. 2010, 1, 137-144.

[16]. Abdelhamid, A. O.; Afifi, M. A. M. Synthetic Commun. 2010, 40, 1539-1550.

[17]. Abdelhamid, A. O.; Abdelall, E. K. A.; Abdel-Riheem, N. A.; Ahmed, S. A. Phosphorus, Sulfur, Silicon and Relat. Elem. 2010, 185, 709-718.

[18]. Abdelall, E. K. A.; Mohamed, M. A.; Abdelhamid, A. O. Phosphorus, Sulfur, Silicon and Relat. Elem. 2010, 185, 1862-1874.

[19]. Abdelhamid, A. O. J. Heterocycl. Chem. 2009, 46, 680-686.

[20]. Abdelhamid, A. O.; Ismail, Z. H.; Abdel-Gawad, S. M.; Ghorab, M. M.; Abdel-Aziem, A. Phosphorus, Sulfur, Silicon and Relat. Elem. 2009, 184, 58-75.

[21]. Rupe, H. Chem. Ber. 1897, 30, 1097-1100.

[22]. Abdallah, M. A. Z. Naturforsch, 2002, 57b, 699-706.

[23]. Abdelhamid, A. O.; Parkanyi, C.; Shawali, A. S.; Abdalla, M. A. J. Heterocycl. Chem. 1984, 21, 1049-1054.

[24]. Emam, H. A.; Abdelhamid, A. O. Phosphorus, Sulfur, Silicon and Relat. Elem. 1997, 131, 37-48.

[25]. Abdelhamid, A. O.; Emam, H. A.; Abdel-Reheem, N. A. J. Chem. Res. 1999, 532, 2323-2335.

[26]. Abdelhamid, A. O.; Abdelaziz, H. M. Phosphorus, Sulfur, Silicon and Relat. Elem. 2007, 182, 2791-2800.

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