Synthesis of 5-arylazothiazoles, pyridines and  thieno[2,3-b]pyridines derivatives containing 1,2,3-triazole moiety

Abdou Osman Abdelhamid; Nadia Abdelhamid Abdel-Riheem; Tamer Tawhid El-Idreesy; Huda Refat Mahmoud Rashdan

doi:10.5155/eurjchem.3.3.322-331.629

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Published: Sep 30, 2012

DOI: https://doi.org/10.5155/eurjchem.3.3.322-331.629

Keywords:

Urea, Pyridines, Carbamates, Quinazoline, 5-Arylthiazoles, Thieno[2, 3-b]pyridines

Section

Research Article

Issue

Vol. 3 No. 3 (2012): September 2012

Dates

Received 2012-05-04
Accepted 2012-06-25
Published 2012-09-30

Abdou Osman Abdelhamid

Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

Nadia Abdelhamid Abdel-Riheem

Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

Tamer Tawhid El-Idreesy

Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

Huda Refat Mahmoud Rashdan

Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

Abstract

1-(2-(4,5-dihydro-3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-5-phenylpyrazol-1-yl)-4-subs-tituted-thiazol-5-yl)-2-phenyldiazene (4) and substituted pyridines (5-12) were synthesized via reaction of 1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-3-phenylprop-2-en-1-one with hydrazonoyl halides and active methylene compounds. Also, thieno[2,3-b]pyridines (14a-e) were prepared through reactions of 2-mercapto-6-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-4-phenyl-pyridine-3-carbonitrile with halo ester and halo ketones, respectively. The newly synthesized derivetived were elucidated by elemental analysis, spectral data and alternative synthetic routes wherever possobile.

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Abdelhamid, A. O.; Abdel-Riheem, N. A.; El-Idreesy, T. T.; Rashdan, H. R. M. Synthesis of 5-Arylazothiazoles, Pyridines and thieno[2,3-b]pyridines Derivatives Containing 1,2,3-Triazole Moiety. Eur. J. Chem. 2012, 3, 322-331.

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Supporting Agencies

Cairo University, Giza, Egypt

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