Synthesis and antimicrobial activities of pyrido[2,3-d]pyrimidine, pyridotriazolopyrimidine, triazolopyrimidine, and  pyrido[2,3-d:6,5d']dipyrimidine derivatives

Anhar Abdel-Aziem; Marwa Sayed El-Gendy; Abdou Osman Abdelhamid

doi:10.5155/eurjchem.3.4.455-460.683

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Published: Dec 31, 2012

DOI: https://doi.org/10.5155/eurjchem.3.4.455-460.683

Keywords:

Nitrile imines, 6-Aminothiouracil, Pyridopyrimidines, Hydrazonoyl halides, Pyridotriazolopyrimidines, Pyrido[2, 3-d, 6, 5d']dipyrimidine

Section

Research Article

Issue

Vol. 3 No. 4 (2012): December 2012

Dates

Received 2012-09-25
Accepted 2012-10-30
Published 2012-12-31

Anhar Abdel-Aziem

Department of Chemistry, Faculty of Science (Girls), Azhar University, Nasr City, Cairo, 11754, Egypt

Marwa Sayed El-Gendy

Department of Chemistry, Faculty of Science (Girls), Azhar University, Nasr City, Cairo, 11754, Egypt

Abdou Osman Abdelhamid

Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

Abstract

A new series of pyridotriazolopyrimidines were synthesized via reaction of hydrazonoyl halides with pyrido[2,3-d]pyrimidines. The structures of the newly synthesized compounds were established by elemental analysis, spectral data and alternative synthetic routes whenever possible. Some of synthesized compounds were also screened in vitro for their antimicrobial activity against a variety of bacterial and fungal samples.

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Abdel-Aziem, A.; El-Gendy, M. S.; Abdelhamid, A. O. Synthesis and Antimicrobial Activities of pyrido[2,3-d]pyrimidine, Pyridotriazolopyrimidine, Triazolopyrimidine, and pyrido[2,3-d:6,5d’]dipyrimidine Derivatives. Eur. J. Chem. 2012, 3, 455-460.

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