Synthesis and anti-tumor activities of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives

Sayed Abdelkader Ahmed; Osama Mohamed Ahmed; Abdou Osman Abdelhamid

doi:10.5155/eurjchem.5.2.334-338.910

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Published: Jun 30, 2014

DOI: https://doi.org/10.5155/eurjchem.5.2.334-338.910

Keywords:

Cyclooctane, Cyclohexane, Cyclopentane, Antitumor activity, 1H-1, 2, 4-triazol-5-amine, Triazolo[5, 1-a]pyrimidine

Section

Research Article

Issue

Vol. 5 No. 2 (2014): June 2014

Dates

Received 2013-08-26
Accepted 2013-12-13
Published 2014-06-30

Sayed Abdelkader Ahmed

Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62514 Egypt

Osama Mohamed Ahmed

Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt

Abdou Osman Abdelhamid

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt

Abstract

Condensation of 1H-1,2,4-triazol-5-amine with the appropriate sodium (E)-(2-oxocycloalkylidene)methanolate gave 7,8-dihydro-6H-cyclopenta[e][1,2,4]triazolo [1,5-a]pyrimidine, 6,7,8,9-tetrahydro-[1,2,4]triazolo[1,5-a]quinazoline, 7,8,9,10-tetra hydro-6H-cyclohepta[e][1,2,4]triazolo[1,5-a]pyrimidine and 6,7,8,9,10,11-hexahydro cycloocta[e][1,2,4]triazolo[1,5-a]pyrimidine. Structures of the newly synthesized compounds were elucidated via elemental analyses, spectral (IR, ¹H NMR, ¹³C NMR, 2D NMR), and X-ray single crystal diffraction data. These derivatives showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines.

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Ahmed, S. A.; Ahmed, O. M.; Abdelhamid, A. O. Synthesis and Anti-Tumor Activities of New [1,2,4]triazolo[1,5-a]pyrimidine Derivatives. Eur. J. Chem. 2014, 5, 334-338.

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